The Effect of Probiotic Lactobacillus acidophilus and Ethanolic Propolis Compound toward Nucleic Acid Deposition in the Extracellular Polymeric Substance of Root Canal Bacteria.

Objective:  This study aimed to evaluate the effects of ethanolic propolis and probiotic bacteria on the nucleic acid concentration in the extracellular polymeric substances (EPS) derived from biofilm of root canal bacteria.

Materials And Methods:  Clinical bacteria of the root canal were cultured with ethanolic extract of propolis (EEP; 10 or 0.1%) and .

Evaluation of International Caries Detection and Assessment System (ICDAS)-related Caries Severity among Caries Risk Groups in Pendul District: An Observational Study.

Aim: The aim of this study was to evaluate the difference in severity of caries code 5 or 6 according to the International Caries Detection and Assessment System (ICDAS) among caries risk groups in Pendul district.

Materials And Methods: This was an observational study with a cross-sectional design. A total of 730 people who were residing in Pendul district belonged to population of this study.

Sp6 regulation of Rock1 promoter activity in dental epithelial cells.

Sp6 is a transcription factor of the SP/KLF family and an indispensable regulator of the morphological dynamics of ameloblast differentiation during tooth development. However, the underlying molecular mechanisms remain unclear. We have previously identified one of the Sp6 downstream genes, Rock1, which is involved in ameloblast polarization.

Ctip2-mediated Sp6 transcriptional regulation in dental epithelium-derived cells.

Tooth development relies on the interaction between the oral ectoderm and underlying mesenchyme, and is regulated by a complex genetic cascade. This transcriptional cascade is regulated by the spatiotemporal activation and deactivation of transcription factors. The specificity proteins 6 (Sp6) and chicken ovalbumin upstream promoter transcription factor-interacting protein 2 (Ctip2) were identified in loss-of-function studies as key transcription factors required for tooth development.