Safety and efficacy of early augmentation with Transcranial Direct Current Stimulation (tDCS) in adolescents with Major Depressive Disorder: A randomized controlled trial.

Background: Transcranial Direct Current Stimulation (tDCS) is an emerging modality with demonstrated efficacy in Major Depressive Disorder (MDD), however, there is paucity of research in adolescent depression. This study attempts to evaluate the safety and efficacy of tDCS in adolescents with MDD as an early augmentation to drug therapy.

Methods: Adolescents with MDD aged 10-18 years were enrolled in the study and allocated to active or sham groups as per randomization.

Importin α inhibitors act against the differentiated stages of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii.

Background: Nuclear import, dependent on the transporter importin α (IMPα), is a drug target for apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii. Indeed, a panel of small molecule inhibit interactions between IMPα and nuclear localization signals (NLSs) in vitro and the growth of rapidly dividing stages (P. falciparum blood stages and T.

Echocardiographic Predictors of Ventricular Arrhythmias in Patients With Left Ventricular Assist Devices and Implantable Cardioverter-Defibrillator.

Aim: To evaluate the predictive value of preoperative echocardiographic parameters for occurrence of VAs in patients with preexisting ICD undergoing LVAD implantation.

Methods And Results: All consecutive patients (n = 264) with previous ICD who underwent LVAD surgery between May 2011 and December 2019 at our institution were included. The patients were predominantly male (89%) with NICM (59%) and a mean age of 59 ± 10 years.

Anal tuberculosis presented as chronic perianal abscess in an immunocompetent adult: A rare case report.

There are reported 7.5 million cases of extra pulmonary tuberculosis (TB) (EPTB) worldwide and 19% in the South-East Asia region. Anal TB represents an exceedingly uncommon extra pulmonary manifestation of TB), occurring in fewer than 1% of individuals who acquire TB.

Effect of Fe doping on the electronic properties of CoSn Kagome semimetal.

Quantum phenomena in two-dimensional Kagome materials lead to exotic topological states and complex magnetism. Here, we have investigated the detailed electronic properties of Co1-xFeSn as a function of composition () to explore the competing electronic interactions for the origin of complex magnetism and topological properties. We find that the screening effect in the valence electrons increases while the correlation effect decreases with an increase in the Fe doping.

Assessment of the Microhardness of Three Different Glass Ionomer Cements After Microhydroxyapatite Incorporation: An In Vitro Study.

Aim The study aimed to evaluate the impact of incorporating microhydroxyapatite on the microhardness of three different types of glass ionomer cement. Methodology A total of 120 disc-shaped specimens (7 mm in diameter and 3 mm in height) were prepared for the study, divided into three groups, each containing four subgroups of 10 samples. The materials tested included Zirconomer, conventional glass ionomer cement (CGIC), and resin-modified glass ionomer cement (RMGIC), with the addition of microhydroxyapatite in varying concentrations of 0, 5, 15, and 25 wt%.

Randomized Controlled Trial of Bifrontal Transcranial Direct Current Stimulation on Craving in Alcohol Use Disorder.

Background: Transcranial direct current stimulation (tDCS) is a potential neuromodulation option for the management of cravings in patients with alcohol use disorder (AUD). This study aims to assess the efficacy and safety of tDCS in the management of craving for alcohol and to measure the change in subjective well-being in patients with AUD following tDCS intervention.

Methods: Patients with AUD aged between 18 and 60 years were randomly assigned to active tDCS intervention and sham tDCS intervention groups, each consisting of 17 patients.

Flexural Strength of Different Commercially Available Auto-Polymerizing Acrylic Resins: An In Vitro Study.

Background Auto-polymerizing acrylic resins, composed primarily of poly(methyl methacrylate) and methyl methacrylate, are crucial in prosthetic dentistry due to their ease of use, cost-effectiveness, and acceptable aesthetics, polymerizing at room temperature to form solid polymer networks. One of the most important mechanical properties of these resins is flexural strength, which is essential for their performance under continuous masticatory forces. In clinical applications, prosthetic materials endure repetitive stress from chewing, and resins with higher flexural strength are better equipped to resist deformation and fractures.

Glucagon-like peptide-1 agonists in cardiovascular diseases: a bibliometric analysis from inception to 2023.

Background: In recent years, glucagon-like peptide-1 (GLP-1) agonists have garnered increasing attention for their potential cardiovascular benefits beyond glycemic control in patients with diabetes. Understanding the research landscape surrounding GLP-1 agonists and cardiovascular diseases (CVDs) is crucial for informing clinical practice and guiding future research endeavors. This bibliometric analysis aimed to comprehensively assess the scholarly output and trends in this field, shedding light on the evolving landscape of GLP-1 agonists' role in cardiovascular health.

Prognosis and ablation success in thyroid cancer: overcoming the challenges of incomplete clinical profiles.

Background: Differentiated thyroid carcinoma (DTC) is managed by surgery followed by radioiodine (RAI) therapy in most intermediate and high-risk patients. Most nonmetastatic patients have excellent treatment responses and have long-term disease-free status. A lack of comprehensive medical services in resource-limited nation leads to attrition of critical clinical prognostication information.

PFusionDB: a comprehensive database of plant-specific fusion transcripts.

Unlabelled: Fusion transcripts (FTs) are well known cancer biomarkers, relatively understudied in plants. Here, we developed PFusionDB (www.nipgr.

An In-Vitro Study on the Impact of Light-Emitting Diode (LED) and Laser-Activated Bleaching Techniques on the Color Change of Artificially Stained Teeth at Varying Time Intervals.

Introduction Tooth color is a key factor in the perception of an attractive smile, making bleaching a widely sought-after cosmetic dental procedure. Valued for its minimally invasive approach, this technique effectively lightens teeth to achieve desired aesthetic outcomes. As the desire for immediate results grows among patients, various bleaching agents, and energy sources have been developed to expedite the bleaching process.

Development of a pharmacy technician training program and advanced pharmacy technician roles: A health system's journey amidst an evolving national practice landscape.

In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

Application of chaotic teaching-learning-based optimization technique for estimating unknown parameters of proton exchange membrane fuel cell model.

Proton exchange membrane fuel cells (PEMFC) possess features like high specific power density, low operating temperature, and low operating pressure and thus are most widely used. The performance of PEMFC highly depends on its output voltage which further affects its efficiency. This research paper aims to improve this output voltage by minimizing the losses through parameter estimation technique for three well-known commercial PEMFC stacks, namely, 250W, BCS 500W, and Ballard Mark V.

Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning.

Elucidating how protein sequence determines the properties of disordered proteins and their phase-separated condensates is a great challenge in computational chemistry, biology, and biophysics. Quantitative molecular dynamics simulations and derived free energy values can in principle capture how a sequence encodes the chemical and biological properties of a protein. These calculations are, however, computationally demanding, even after reducing the representation by coarse-graining; exploring the large spaces of potentially relevant sequences remains a formidable task.

Screening Clinical, Laboratory and Host Markers for Diagnosis of Disease Severity in Clinical Samples.

Unlabelled: Malaria is one of the most infectious disease that affects lives of million people throughout the world. Recently, there are several reports which indicate causing severe disease in infected patients from different parts of the world. For disease severity, the data related to immunological and inflammatory status in human host is very limited.

Multiple Sclerosis: Pathogenesis Mechanism and Biomarkers.

Multiple sclerosis (MS) is an unceasing, demyelinating, idiopathic inflammatory, and neurodegenerative disease of the Central Nervous System (CNS.) The disease is characterized by the occurrence of neurological symptoms over a period of days to weeks, abide by partial or absolute diminutions of various durations. In this review, a concise outline on disease activity and progression of MS, pathogenesis with the special prominence on the biomarkers for the MS as therapeutic targets has been discussed by carrying out a comprehensive literature survey employing chief websites and search engines for investigation.