Nano-engineering chitosan particles to sustain the release of promethazine from orodispersables.

Orally dispersing tablets (ODTs), also known as orodispersibles, were first introduced into the market in 1980s to overcome dysphagia problems amongst pediatrics and geriatrics. Despite their abilities to avoid swallowing difficulties, frequency of dosing stood as a barrier for these formulations. The aim of the current study is to produce and optimize a sustained release orally disintegrating tablets (SR-ODT), with the aid of chitosan.

New Generation of Orally Disintegrating Tablets for Sustained Drug Release: A Propitious Outlook.

Orally disintegrating tablets (ODTs) or orodispersible tablets are solid dosage forms that disintegrate within 3 minutes in the mouth into a paste that can be easily swallowed. ODTs have improved over the past years, in an attempt to produce a safe and efficient substitute to the conventional oral dosage forms, particularly for dysphagia patients. Since its introduction in the market in the 1980s, ODTs expanded rapidly and achieved revenues over $3 billion in 2006 and sustaining 20% annual growth.