Publications by authors named "Arwa Alyamani"
Article Synopsis
- Chronic kidney disease (CKD) often leads to anemia, complicating treatment for dialysis-dependent patients, necessitating various therapies including daprodustat, rhEPO, and iron supplements.
- This study aimed to evaluate whether daprodustat is more effective and safer than rhEPO and other standard treatments, using data from seven trials with a focus on systematic review and network meta-analysis.
- Results showed that daprodustat (25-30 mg dosage) significantly improved serum hemoglobin and total iron binding capacity (TIBC) while reducing ferritin levels in these patients, indicating its potential superiority in managing anemia associated with CKD.
Various factors can be linked to an increase in platelet count. Yet thrombocytosis could be essential. Many genetic mutations have been associated with essential thrombocytosis, which also increases the possibility of myelofibrotic transformation.
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- Anemia is common in chronic kidney disease (CKD) patients, affecting around 40%; daprodustat helps improve hemoglobin levels by targeting a specific enzyme linked to oxygen response.
- A network meta-analysis was performed on randomized clinical trials to compare various doses of daprodustat against erythropoietin and placebo in CKD patients not on dialysis.
- Results showed that higher doses of daprodustat significantly increased hemoglobin levels and altered iron markers, but more safety data is needed on its different dosages.
Chronic immune thrombocytopenia (ITP) is less commonly found in the children presenting with ITP. Patients usually present with petechiae, purpura, or active bleeding in the form of epistaxis or hematuria. The main aim of treatment in chronic ITP is to prevent major bleeding and to increase the platelet count.
View Article and Find Full Text PDFBackground: Acromegaly is a rare disease resulting in clinical sequelae with significant morbidity and mortality due to the central tumor mass effect and prolonged growth hormone (GH) hypersecretion.
Objectives: The goal is to describe the epidemiology, clinical features, presence of comorbidities, and treatment outcomes of acromegaly in Saudi Arabia.
Methods: Data was collected through a retrospective review of the charts of all patients diagnosed with acromegaly from nine major hospitals in Saudi Arabia over a period of more than 25 years.
Article Synopsis
- Cancer treatment shortages are a widespread issue in Saudi Arabia, affecting patient outcomes and requiring immediate attention from healthcare professionals.
- A qualitative study with 55 oncology experts revealed that 100% of respondents encounter these shortages, averaging five instances per month.
- The panel identified a need for standardized definitions of drug shortages and proposed nine actionable recommendations to improve the current system and better manage resources.
Background And Objective: Each year millions of Muslims perform pilgrimage to Makkah, Saudi Arabia. It is particularly stressful during the peak five days, when all rituals have to be performed at specific periods of time at different sites. Poor diabetes control in people with diabetes predisposes to morbidity and increases risk of acute complications.
View Article and Find Full Text PDFBackground: Acute lymphoblastic leukemia (ALL) in children with Down syndrome (DS) presents with an increased incidence, higher frequency of adverse effects and inferior probability of survival. Attempts at improving outcomes face the dilemma posed by the need to avoid excessive toxicity while maintaining the efficacy of treatment. Dose reductions and avoidance of infusions of intermediate and high-dose methotrexate are common in this group.
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