Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33.

Background: Staphylococcus aureus is the dominant infective trigger of atopic dermatitis (AD). How this bacterium drives type 2 allergic pathology in the absence of infection in patients with AD is unclear.

Objective: We sought to identify the S aureus-derived virulence factor(s) that initiates the cutaneous type 2-promoting immune response responsible for AD.

Internalized by Skin Keratinocytes Evade Antibiotic Killing.

causes the majority of skin and soft tissue infections. Half of patients treated for primary skin infections suffer recurrences within 6 months despite appropriate antibiotic sensitivities and infection control measures. We investigated whether internalized by human skin keratinocytes are effectively eradicated by standard anti-staphylococcal antibiotics.