Publications by authors named "Arvinder Hunjan"
Introduction: Performance of the amyloid tracer [F]flutemetamol was evaluated against three pathology standard of truth (SoT) measures including neuritic plaques (CERAD "original" and "modified" and the amyloid component of the 2012 NIA-AA guidelines).
Methods: After [F]flutemetamol imaging, 106 end-of-life patients who died underwent postmortem brain examination for amyloid plaque load. Blinded positron emission tomography scan interpretations by five independent electronically trained readers were compared with pathology measures.
Article Synopsis
- In vivo imaging of brain β-amyloid can help assess suspected Alzheimer's disease.
- The study evaluated the effectiveness of positron emission tomography (PET) with flutemetamol injection for detecting β-amyloid by using actual neuritic plaque levels as a benchmark.
- Conducted at multiple sites in the U.S. and England, the study involved terminally ill patients aged 55 and older, focusing on the accuracy of PET scans in identifying β-amyloid presence prior to their autopsy.