Isolation and characterization of a novel flavanone glycoside from an endemic plant .

The chemical characterization study of an endemic plant, is (Wight) R.B. Majumdar from Western Ghats of India, resulted in to the isolation of a new flavanone glycoside, 5-hydroxy-7-methoxy-8-O--D-glucopyranosyl-2S-flavanone (), along with 3 known flavonoids, 7-O-methyl dihydrowogonin (), 7-O-methyl wogonin (), andrographidine C ().

(E)-9-oxooctadec-10-en-12-ynoic acid from Ixora brachiata Roxb. increases glucose uptake in L6 myotubes by activating the PI3K pathway.

In an attempt to discover new scaffolds for anti-diabetic activity from plants, we screened extracts from Ixora brachiata Roxb. for their effect on glucose uptake in L6 myotubes. The petroleum (PE) extract of the plant showed a significant increase in insulin stimulated glucose uptake by L6 myotubes.

Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats.

Objective: To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats.

Methods: The antiarthritic activity of 70% ethanolic extract of Ajuga bracteosa (EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund's adjuvant (CFA)-induced chronic immunological arthritis in albino rats.

Results: EEAB showed a significant (P<0.

NF-κB dependent anti-inflammatory activity of chlorojanerin isolated from Saussurea heteromalla.

Medicinal plants have shown great promise as a source of novel drug compounds for the treatment of inflammatory disorders. In our search for new entities with anti-inflammatory potential, the extracts of the whole plant of Saussurea heteromalla (family-Asteraceae), collected from Himalayas, were evaluated in the high throughput screen for TNF-α and IL-6 inhibitors. The extract blocked TNF-α and IL-6 production in LPS stimulated THP-1 cells (human acute monocyte leukemia cell line) completely at 10 and 30 μg/ml.

Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition.

Ethnopharmacological Relevance: Ajuga bracteosa Wall Ex Benth. (Labiateae) is described in Ayurveda for the treatment of rheumatism, gout, palsy and amenorrhea.

Aim Of The Study: The aim of present investigation is to study anti-inflammatory activity of Ajuga bracteosa, to understand possible mechanism of action and to identify the constituents responsible for its activity.

Anti-inflammatory, cyclooxygenase (COX)-2, COX-1 inhibitory and antioxidant effects of Dysophylla stellata Benth.

The n-hexane and ethyl acetate extracts of whole plants of Dysophylla stellata significantly inhibited edema when applied topically at doses of 0.5 and 1mg/ear in TPA-induced ear edema assay in mice. Further, both the extracts were evaluated for COX-1 and COX-2 inhibitory activities and showed 85.

Plant-derived compounds in clinical trials.

Plants remain an important source of new drugs, new drug leads and new chemical entities. The plant-based drug discovery resulted mainly in the development of anticancer and anti-infectious agents and continues to contribute to the new leads in clinical trials. A total of 91 plant-derived compounds in clinical trials as of September 2007 are described in this review.

Indian medicinal plants as a source of antimycobacterial agents.

It is estimated that one-third of the world's population is infected with tubercle bacillus and the problem of tuberculosis (TB) has been intensified due to HIV pandemic providing a large reservoir of highly susceptible individuals. Since no anti-TB drugs have been introduced in past 30 years, there is an urgent need to search for and develop new, effective and affordable anti-TB drugs. In this scenario, the plant kingdom with enormous chemical diversity may be looked as an important source of new anti-TB agents.