[Physical rehabilitation for ankle joint injuries in elderly and elderly people (Stage 2).].

The main part of the injuries of elderly and senile patients as a result of physical activity falls on the lower limbs, due to the increased load during movement. Ankle injuries have a multifactorial etiology involving the interaction of compensatory spinal and leg biomechanics, environmental factors, and shoe selection. In this regard, it is necessary to prepare a complex of rehabilitation measures, including physical therapy, with the possibility of implementing the recovery process not only on an outpatient basis, but also at home, thereby improving the quality of life and preventing disability.

[Physical rehabilitation for ankle joint injuries in elderly and elderly people (Stage 1).].

A multidisciplinary approach to recovery after injuries of the ankle joint in elderly and senile people by specialists of various profiles using drug and non-drug methods is especially relevant today. It is required to develop and put into practice various options for the combined use of physical rehabilitation means at different stages of the rehabilitation treatment of elderly and senile patients with this pathology. The study revealed no significant complications and side effects when using this technique, which allows us to recommend it as a means of secondary prevention and injuries of the ankle joint, especially with contraindications to the use of non-steroidal anti-inflammatory drugs and glucocorticosteroids.

[Current issues of disability and rehabilitation of elderly and senile patients with lower limb loss due to vascular pathology.].

The majority of patients with amputation defect of the lower extremities are elderly citizens with high co- and polymorbidity, the presence of several geriatric syndromes, which adversely affects the prognosis, reduces the rehabilitation potential, in some cases leads to the development of cardiovascular complications, amputation of the second limb, severe disability and high postoperative mortality. The key link in the rehabilitation process of disabled people with a lower limb stump is to provide them with a functional prosthesis. The article provides an analysis of morbidity, primary disability in the period from 2015 to 2019, gender, age and clinical characteristics of patients living in St.

[Antioxidative properties of geroprotective peptides.].

The results of studies on the antioxidant effect of a number of peptide drugs, which is manifested at various levels, ranging from cells to the whole body, in adulthood and during aging, under the influence of extreme environmental factors, indicate the important role of low-molecular peptides in the mechanisms of regulating homeostasis during aging. The antioxidant properties of regulatory peptides are shown in experiments both on intact sexually mature animals, and especially clearly during aging or the action of extreme environmental factors (hypoxia, hypokinesia). A number of the studied substances (AEDG, KE) have a membrane-stabilizing effect, preventing osmotic and acid hemolysis of red blood cells and reducing the level of extra-erythrocyte hemoglobin and total peroxidase activity in blood plasma.

[Assessment of barriers in people with disabilities with ophthalmopathology and varying degrees of sensory impairment to substantiate the list of support services they need and social protection measures in different areas of life.].

The assessment of barriers in persons older than working age with visual impairment was carried out using the International Classification of Functioning, Disabilities and Health to substantiate the list of necessary support services. An increase in the absolute number of people in older age groups objectively leads to an increase in the number of citizens experiencing difficulties in solving medical, social and psychological problems. Analysis of the results of the study showed that a significant part of people, due to impaired visual functions, experience limitations and barriers in physical environment, emotional sphere, family relationships with close and distant relatives.

[Evaluation of the effectiveness of the third stage of rehabilitation after a knee joint injury in persons of older age groups by means of physiotherapy exercises.].

The main task in the rehabilitation of athletes with traumatic injuries of the knee joint and surrounding soft tissues is effective and painless recovery at all stages of treatment. The aim of this work is to introduce a set of physical exercises for the treatment and prevention of traumatic injuries of the knee joint in middle-aged and elderly patients at the third stage of rehabilitation treatment (ICD-10: S80-S89). To date, there is no single regulated program for the management of middle-aged and elderly patients at the outpatient stage.

[Nordic walking in an integrated approach to improving the quality of life of the elderly.].

The article analyzes the results of the impact of an integrated approach to lifestyle modification, including Nordic walking, rational nutrition and pharmacotherapy, on the quality of life of elderly people (average age 72,5±3,6 years). A significant improvement in the pain scale indicator of the MOS SF-36 was revealed after six months (p=0,001), which was also determined by the end of the year (p=0,0001). A tendency to improve the quality of life was revealed in the Minnesota Questionnaire after six months (p=0,0617).

[The role of a lysine residue in the antioxidant and dna-protective activity of oligopeptides].

Oligopeptides present in the living cell were found to have antioxidative activity and to be involved in the regulation of antioxidant balance by interaction with the redox-dependent cellular signaling cascades. Experiments on animal models have shown that the introduction of oligopeptides causes geroprotective and adaptogenic effects. In the present work, we investigate the biological action of a number of synthetic oligopeptides using bacterial biosensors.

[The role of oxidative stress in skin aging].

The review covers the literature proving that ROS formation in aging overbalances the antioxidant defense system potential of the skin structure (horny layer, epidermis and dermis). It has been shown that ROS are involved in the pathogenesis of inflammatory processes and allergic responses in the skin. The role of ROS and antioxidant systems in the cell-mediated responses associated with the MAP kinase activity in the skin is discussed.

[Regional differentiation of ageing characteristics in Russia].

Regional differences in ageing characteristics in Russia have been studied. A number of ageing characteristics (e.g.

[Morphology of experimental pneumoconiosis developing after exposure to lunar soil].

Intratracheal administration to rats of a thin fraction of lunar material delivered by the Luna-16 automatic station from the Sea of Abundance gives rise to pneumoconiosis. The disease is characterized by the formation of granulation tissue consisting of lymphoid cells, macrophages, fibroblasts and cell cooperations (rosettes), by thickening of the basal layer of the aerohematic barrier, by the development of the immune process, blockade of the terminal parts of the lymphatic network, and by the development of the fibrous process. As regards the intensity of fibrous tissue formation, the lunar material might be attributed to the group of weak-fibrogenous dust as compared, for instance, with quartz.

[Types of filariasis].

On the basis of the work in tropical Africa the authors describe the diseases little known in the Soviet Union: wuchereriosis and onchocerciasis. Wide international contacts with countries of hot climate (Asia, Africa, America) as well as the possibility of infection of Soviet people living in these regions for long periods do not exclude importation of these highly communicable diseases into the country. The epidemiology, clinical patterns and pathological anatomy of wuchereriosis and onchocerciasis are presented briefly.

[Electron microscopic study of the tissue reaction of lungs exposed to quartz dust of varying dispersity].

The tissue reaction of the lungs exposed to quartz dust of varying dispersity was studied by light, transmission and scanning electron microscopy. It is suggested that specific clinical manifestations of dust pathology are related to dispersity of silica. The largest quartz-containing dust particles give rise chiefly to the development of dust bronchitis.

[Morphologic features of erythrocytes in normal subjects and in anemia caused by lead poisoning (electron microscopic study)].

The methods of scanning and transmission electron microscopy were used to study erythrocytes from normal subjects and those suffering from anemia of lead poisoning genesis. Erythrocytes from normal subjects were shown to have predominantly convex-concave and biconcave shapes. An insignificant portion of ageing erythrocytes of spherical shape and decreased volume had granular surface and consolidated hemoglobin.

[Cytopharmacologic effect of using polyvinylpyridine-N-oxide in experimental silicosis].

Methods of scanning, transmission electron microscopy and cytochemistry were applied to the study of the development of experimental silicosis against the background of polyvinylpyridine-N-oxide administration. The majority of the macrophages retained their functional activity and realized quartz phagocytosis, eliminating it through the airway. Bringing the proteins on the cell surface in the fibroblasts was delayed, and formation of collagen fibers decreased.

[Fibroblast differentiation during collagen formation].

The successive differentiation in the series lymphocyte--(lymphocyte-type cell--precursor)--weakly differentiated cell (polyblast)--profibroblast--fibroblast was shown by means of scanning and transmission electron microscopy. In the focus of aseptic inflammation and in the zones of pneumosclerosis (silicosis), the ultrastructural and cytochemical cell rearrangement took place which was accompanied by the development of protein synthesizing organelles and the formation of folded surface. The collagen fibers run from the surface of the differentiated fibroblasts in the ground substance and preserve the direction of their growth with respect to the spatial position of cells.

[Cellular contacts and "cytoplasmic bridges" in the inflammation focus (scanning and transmission electron microscopic study)].

Contacts between cells in an inflammation focus were studied by the methods of scanning (raster) and transmission electron microscopy on a model of aseptic inflammation in the subcutaneous connective tissue in rats. It is shown that contacts among the cells of the connective tissue and the blood in the form of "cytoplasmatic bridges", observed in the scanning electron microscope, were not confirmed by the studies in the transmission microscope. The investigation of the "cytoplasmatic bridges" in the transmission electron microscope revealed a close adjacence of the cytolemma of the contacting cells, or a harrow space between them as wide as 10-30 micron.

[Characteristics of the terminal segments of the lymphatic system of microcirculation according to the data of scanning electron microscopy].

Lymphatic capillaries and postcapillaries in the system of the connective tissue were studied by the method of scanning (raster) electron microscopy. It was shown that these capillaries consisted of chains of ballon-shaped structures-sinuses. Lymphatic capillaries represent an open system which is communicated with the intercellular matter of the connective tissue by means of openings ensuring filtration of the tissue liquid.