Artificial blood for therapeutic and laboratory usage: Where do we stand?

The scarcity of blood for transfusion purposes has been widely acknowledged. Surgical therapeutic processes, war zones, and post-disaster treatments demand a huge amount of blood. Modern-day laboratories also require blood for bioengineering experimentation.

Biotribological behaviour, biodegradability and osteocompatibility of Mg-3Zn/HA composite based intramedullary inserts in avian model.

Bioactivity, structural integrity and tribological behaviour of biodegradable orthopaedic fracture fixing accessories considerably impact their actual performance in the body environment. Immune system in the living body quickly responds to the wear debris as foreign material and begins a complex inflammatory response. Magnesium (Mg) based biodegradable implants are widely studied for temporary orthopaedic applications, due to their similar elastic modulus and density to natural bones.

Effect of left ventricular assist device on the hemodynamics of a patient-specific left heart.

This article describes the numerical efforts made to investigate the influence of a left ventricular assist device (LVAD) on the patient-specific left heart's hemodynamics. Two different computational geometries with left heart have been simulated over the entire cardiac cycle (case 1: healthy heart without LVAD and case 2: diseased heart with LVAD). The blood flow was simulated by implementing Bird-Carreau non-Newtonian model.

Comparative assessment of different versions of axial and centrifugal LVADs: A review.

Continuous-flow left ventricular assist devices (LVADs) have gained tremendous acceptance for the treatment of end-stage heart failure patients. Among different versions, axial flow and centrifugal flow LVADs have shown remarkable potential for clinical implants. It is also very crucial to know which device serves its purpose better to treat heart failure patients.

Biocompatibility and biodegradability evaluation of magnesium-based intramedullary bone implants in avian model.

At present days osteosynthesis modalities for avian fracture management are inadequate. External coaptation is the most practiced method however, specialized clinics have started introducing intramedullary pinning, external skeletal fixation with tie-in-fixation for fracture immobilization. Magnesium (Mg) based biomaterials are trustable developments in the field of orthopedics compared to their permanent stainless steel counterparts concerning long term adverse reaction.

Simulation of Blood as Fluid: A Review From Rheological Aspects.

Blood flow in the human vascular system is a complex to understand example of fluid dynamics in a closed conduit. Any irregularities in the hemodynamics may lead to lethal cardiovascular disease like heart attack, heart failure and ischemia. Numerical simulation of hemodynamics in the blood vessel can facilitate a thorough understanding of blood flow and its interaction with the adjacent vessel wall.

Proposal of hemodynamically improved design of an axial flow blood pump for LVAD.

Left ventricular assist devices (LVAD) emerges as an effective clinical device providing life-saving support to heart patients. The design of blood pump of an LVAD involves incredible accuracy and thorough understanding of hemodynamics to mimic the functionality of a healthy ventricle. This work studies hemodynamics around an LVAD and proposes an improved model of axial blood pump for cardiac circulation without any hemolysis complications through numerical investigations.

Numerical simulation of centrifugal and hemodynamically levitated LVAD for performance improvement.

Left ventricular assist device (LVAD) provides an effective artificial support system to the heart patients. Despite the improved life survival rate, complications like hemolysis, blood trauma, and thrombus formation still limit the performance of the blood pump. The geometrical aspects of blood pumps majorly influence the hemodynamics, therefore these devices must be carefully engineered.

Discordance in self-report and observation data on mistreatment of women by providers during childbirth in Uttar Pradesh, India.

Background: The study aims to assess the discordance between self-reported and observed measures of mistreatment of women during childbirth in public health facilities in Uttar Pradesh, India, as well as correlates of these measures and their discordance.

Methods: Cross sectional data were collected through direct observation of deliveries and follow-up interviews with women (n = 875) delivering in 81 public health facilities in Uttar Pradesh. Participants were surveyed on demographics, mistreatment during childbirth, and maternal and newborn complications.

Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene induce partial oncolysis of Canine Transmissible Venereal Tumor.

The oncolytic effect of Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene in naturally occurring cases of Canine Transmissible Venereal Tumor (CTVT) is being reported. Dogs suffering from CTVT (N = 18) were systematically randomized into three groups viz. A, B, and C (n = 6).

Associations Between Mistreatment by a Provider during Childbirth and Maternal Health Complications in Uttar Pradesh, India.

Objectives This study assesses associations between mistreatment by a provider during childbirth and maternal complications in Uttar Pradesh, India. Methods Cross-sectional survey data were collected from women (N = 2639) who had delivered at 68 public health facilities in Uttar Pradesh, participating in a quality of care study. Participants were recruited from April to July 2015 and surveyed on demographics, mistreatment during childbirth (measure developed for this study, Cronbach's alpha = 0.

Coalescence of sessile microdroplets subject to a wettability gradient on a solid surface.

While there are intensive studies on the coalescence of sessile macroscale droplets, there is little study on the coalescence of sessile microdroplets. In this paper, the coalescence process of two sessile microdroplets is studied by using a many-body dissipative particle dynamics numerical method. A comprehensive parametric study is conducted to investigate the effects on the coalescence process from the wettability gradient, hydrophilicity of the solid surface, and symmetric or asymmetric configurations.