A Study of Disability Severity, Barriers, and Facilitating Factors in Accessing Healthcare Among Differently Abled Adults.

Background: Disability impacts many individuals, thus restricting access to necessary healthcare. Barriers that affect health equity among people with disabilities include physical inaccessibility, financial constraints, and stigma in society. This study aims to report on the level of disability and factors determining healthcare access among adult differently abled persons in Chennai, Tamil Nadu, focusing on the WHO Disability Assessment Schedule (WHODAS 2.

Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy.

Cancer progression is primarily driven by the uncontrolled activation of cellular signaling pathways, with the PI3K/Akt/mTOR (PAMT) pathway playing a central role. This pathway significantly contributes to the proliferation and survival of cancer cells, and its hyperactivity is a major challenge in managing several types of malignancies. This article delves into the promising potential of carotenoids, natural pigments found in abundance in fruits and vegetables, as a novel therapeutic strategy for cancer treatment.

My turn or yours? Me-you-distinction in feature-based action planning.

Binding accounts propose that action planning involves temporarily binding codes of the action's unique features, such as its location and duration. Such binding becomes evident when another action (B) is initiated while maintaining the Action Plan A. Action B is usually impaired if it partially overlaps with the planned Action A (as opposed to full or no feature overlap).

Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity.

The efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells, which is sensitive to the tumor microenvironment. Whether ionic signals affect adaptive antitumor immune responses is unclear. In the present study, we show that there is an enrichment of sodium in solid tumors from patients with breast cancer.

Cling together, swing together? Assessing indirect retrieval of stimulus-response bindings for associated stimuli.

When a stimulus is paired with a response, a stimulus-response (SR) binding (or event file) is formed. Subsequent stimulus repetition retrieves the SR binding from memory, which facilitates (impedes) performance when the same (a different) response is required. We aimed to explore whether indirect retrieval of SR bindings by a newly learnt associated stimulus is possible.

Deciphering Bisphenol A degradation by Coelastrella sp. M60: unravelling metabolic insights through metabolomics analysis.

Microalgae, owing to their efficacy and eco-friendliness, have emerged as a promising solution for mitigating the toxicity of Bisphenol A (BPA), a hazardous environmental pollutant. This current study was focused on the degradation of BPA by Coelastrella sp. M60 at various concentrations (10-50 mg/L).

One Link to Link Them All.

A conditioned response to a stimulus can be transferred to an associated stimulus, as seen in sensory preconditioning. In this research paper, we aimed to explore this phenomenon using a stimulus-response contingency learning paradigm using voluntary actions as responses. We conducted two preregistered experiments that explored whether a learned response can be indirectly activated by a stimulus (S1) that was never directly paired with the response itself.

Hesperidin Methyl Chalcone reduces extracellular Aβ peptide aggregation and fibrillation and also protects Neuro 2a cells from Aβ induced neuronal dysfunction.

In the present study, we evaluated the neuroprotective potential of Hesperidin Methyl Chalcone (HMC) against the neurotoxicity induced by Aβ peptide HMC demonstrated higher free-radical scavenging activity than Hesperidin in initial cell-free studies. Investigations using the fluorescent dye thioflavin T with Aβ peptide showed that HMC has the ability to combat extracellular amyloid aggregation by possessing anti-aggregation property against oligomers and by disaggregating mature fibrils. Also, the results of the molecular simulation studies show that HMC ameliorated oligomer formation.

Human T17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.

It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) is a membrane pore-forming molecule that has been shown to execute pyroptotic cell death and thus to serve as a potential cancer checkpoint.

Review on rewiring of microalgal strategies for the heavy metal remediation - A metal specific logistics and tactics.

Phycoremediation of heavy metals are gaining much attention and becoming an emerging practice for the metal removal in diverse environmental matrices. Still, the physicochemical state of metal polluted sites is often found to be complex and haphazard in nature due to the irregular discharge of wastes, that leads to the lack of conjecture on the application of microalgae for the metal bioremediation. Besides, the foresaid issues might be eventually ended up with futile effect to the polluted site.

Being in the Know: The Role of Awareness and Retrieval of Transient Stimulus-Response Bindings in Selective Contingency Learning.

Previous studies demonstrated that contingency learning can be both (a) unaware (Schmidt et al., 2007), and (b) explained in terms of an automatic retrieval of stimulus-response bindings from the last episode in which the cue stimulus has been presented (Giesen et al., 2020; Schmidt et al.

Built-In Calibration Standard and Decision Support System for Controlling Structured Data Storage Systems Using Soft Computing Techniques.

Several research that assesses, or assess computer systems has been undertaken in previous decades. Choosing an appropriate DBMS system in a computer application, though, was never completely arbitrary, based on the professional study. Developing a viable answer for such a challenge depending on business goals and needs from judgment necessitates a thorough study on information access as well as comprehensive professional evaluation.

2D/2D Nanoarchitectured NbC/TiC MXene Heterointerface for High-Energy Supercapacitors with Sustainable Life Cycle.

Layered 2D/2D heterointerface composites experience interesting properties that greatly stimulate the recent surge in the attention as robust supercapacitor electrode materials, especially the MXene-based 2D/2D heterointerface for its robust energy storage compatibility. This report unveils a synergistically in situ prepared 2D/2D NbC/TiC MXene (NCTC) heterointerface nanoarchitecture by facile one-pot chemical etching. The methodology adopted enables the interconnected and simultaneous growth of MXenes exposing and retaining their active surfaces for enhanced ion diffusion pathways, charge storage dynamics, microstructural stability, and a noticeable potential window.

Probing marine brown macroalgal phlorotannins as antiviral candidate against SARS-CoV-2: molecular docking and dynamics simulation approach.

Over the past year, owing to the emergent demand for the search for potential COVID-19 therapeutics, identifying alternative candidates from biological sources is one of the sustainable ways to reinforce the drug discovery process. Marine macroalgae have numerous advantages because of the richest availability of underexploited bioactive compounds. Polyphenolic compounds like phlorotannins obtained from brown macroalgae are reported as proven antiviral and immunostimulatory agents.

T-Cell Receptor Repertoire Analysis with Computational Tools-An Immunologist's Perspective.

Over the last few years, there has been a rapid expansion in the application of information technology to biological data. Particularly the field of immunology has seen great strides in recent years. The development of next-generation sequencing (NGS) and single-cell technologies also brought forth a revolution in the characterization of immune repertoires.

Influence of meteorology, mobility, air mass transport and biomass burning on PM of three north Indian cities: phase-wise analysis of the COVID-19 lockdown.

Recent studies concluded that air quality has improved due to the enforcement of lockdown in the wake of COVID-19. However, they mostly concentrated on the changes during the lockdown period, and the studies considering the consequences of de-escalation of lockdown are inadequate. Therefore, we investigated the changes in fine particulate matter (PM) during the pre-lockdown, strict lockdown, unlocking, and post-lockdown scenarios.

Benign recurrent intrahepatic cholestasis - 2 (BRIC-2)/ABCB11 deficiency in a young child - Report from a tertiary care center in South India.

ABCB11 deficiency, formerly benign recurrent intrahepatic cholestasis (BRIC) is a very rare hereditary disorder characterized by the recurrent and intermittent episodes of cholestasis, jaundice, and pruritus. We report the case of a 12-year-old boy presenting with recurrent episodes of jaundice and severe pruritis since childhood. An extensive workup was done to rule out all the possible etiologies.

Does Neuronal Recycling Result in Destructive Competition? The Influence of Learning to Read on the Recognition of Faces.

Written language, a human cultural invention, is far too recent a development for dedicated neural infrastructure to have evolved in its service. Newly acquired cultural skills, such as reading, thus recycle evolutionarily older circuits that originally evolved for different, but similar, functions (e.g.

The role of the written script in shaping mirror-image discrimination: Evidence from illiterate, Tamil literate, and Tamil-Latin-alphabet bi-literate adults.

Learning a script with mirrored graphs (e.g., d ≠ b) requires overcoming the evolutionary-old perceptual tendency to process mirror images as equivalent.

Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations.

Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence.

Importance of Electrode Preparation Methodologies in Supercapacitor Applications.

The work reported here aims toward the optimization of electrode preparation methodologies for superior performance of supercapacitors through a rigorous understanding of underlying physical parameters. Oxygen-functionalized few-layer graphene was employed as an active material while binders [Nafion, polyvinylidene fluoride (PVDF), and polytetrafluoroethylene], solvents for active material dispersion [ethylene glycol and -methyl-2-pyrrolidone (NMP)], and electrode-drying temperatures (100, 170, and 190 °C) were varied. Maximum specific capacitances at different electrode preparation conditions ranged from 240 to 318 F g at 1 mV s scan rate of cyclic voltammetry for the same active material.

Multilocus sequence typing (MLST) of leptospiral strains isolated from two geographic locations of Tamil Nadu, India.

Here the rodent carrier status for the transmission of human leptospirosis in Tiruchirappalli, district, Tamil Nadu, India was assessed. The predominantly circulating leptospiral STs were recognized by multilocus sequence typing (MLST). A total of 113 rodents were trapped from different provinces of the Tiruchirappalli district.

Unusual case of temporal dermoid cyst presenting as oculomotor nerve palsy.

Dermoid cysts are choristomas resulting from the inclusion of ectodermal tissue during closure of the neural tube and occur along the epithelial lines of fusion. Frontotemporal dermoids are the most common type and generally present as an asymptomatic mass. We present an unusual case of frontotemporal dermoid presenting as sudden onset oculomotor nerve palsy in young male patient and describe the neurosurgical approach in its management.

Clinical evaluation of porous hydroxyapatite bone graft (Periobone G) with and without collagen membrane (Periocol) in the treatment of bilateral grade II furcation defects in mandibular first permanent molars.

Background: Furcation invasions represent one of the most demanding therapeutic challenges in periodontics. This investigation assessed and compared the clinical efficacy of hydroxyapatite bone graft material when used alone and with collagen membrane in the treatment of grade II furcation defects.

Materials And Methods: Ten patients with comparable bilateral furcation defects in relation to mandibular first molars were selected and treated in a split-mouth design.