Juvenile Scleroderma.

Localised scleroderma and systemic sclerosis are rare chronic fibrosing disorders seen in children, and are collectively referred to as Juvenile Scleroderma. Histopathology of the two forms is non-distinct but they differ in terms of vasculopathy, internal organ involvement, morbidity and mortality. Raynaud's phenomenon with digital tip ulcers is considered hallmark of systemic sclerosis.

Role of colors in prosthodontics: application of color science in restorative dentistry.

Shade selection procedure depends on various factors including translucency, contour and surface texture. Tooth shade selection using a conventional means involves a high degree of subjectivity. Traditional shade guides are available that use several methods for quantifying shade.

The effectiveness of magnesium oxide combined with tissue conditioners in inhibiting the growth of Candida albicans: an in vitro study.

Context: The presence of Candida albicans on the fitting surface of the denture is a major causative factor in denture stomatitis. A treatment method is by combining tissue conditioner and antifungal agents.

Aims: The main objective of this study is to test the efficacy of magnesium oxide combined with two tissue conditioners (Viscogel and GC Soft), in inhibiting the growth of Candida albicans.

Lasers in prosthodontics - An overview part 1: Fundamentals of dental lasers.

The introduction of lasers in the field of prosthodontics has replaced many conventional surgical and technical procedures and is beginning to replace the dental handpiece. Although lasers were introduced in dentistry as early as the 1960s it has gained widespread popularity mainly in the developed countries only from the early 90s. Today, prosthodontists can select from a variety of laser wavelengths available in dentistry.

Effect of axial groove and resin luting cements on the retention of complete cast metal crowns.

Background: The design of the tooth preparation and the cementing medium are important consid-erations in the retention of crowns and fixed partial dentures. The purpose of this invitro study was to determine the effect of axial groove on the retention of complete cast metal crowns using two resin luting cements.

Methods: Forty freshly extracted intact human molar teeth were prepared in their long axis to receive complete cast metal crowns.

Prosthetic rehabilitation of a completely edentulous patient with palatal insufficiency.

This article presents a case report of a completely edentulous patient with palatal insufficiency successfully rehabilitated with closed hollow bulb obturator prosthesis and also describes a simple technique for fabricating a two-piece hollow bulb obturator that allows for control of the bulb's wall thickness and weight of the prosthesis.

Evidence for multiple P2Y receptors in trabecular meshwork cells.

The purpose of this study was to determine whether functional purinergic P2 receptors are present in trabecular meshwork cells. The human trabecular cell line HTM-3 and cultured bovine trabecular cells were used to assess the effects of P2 agonists on intracellular Ca(2+) levels, extracellular signal-regulated kinase (ERK1/2) activation, and P2Y receptor expression. ATP, UTP, ADP, and 2-methyl-thio-adenosine triphosphate (2-MeS-ATP) each produced a concentration-dependent increase in intracellular Ca(2+) in bovine trabecular cells and the HTM-3 cell line.

p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2.

Previous studies have shown that mitogen-activated protein kinase (MAPK) cascades signal the induction of inducible nitric-oxide synthase (iNOS) in glial cells (Bhat, N. R., Zhang, P.