Publications by authors named "Arun Yadav"

Introduction: Hearing amplification devices provide ample auditory input that can help to decrease the cognitive strain caused by hearing loss. Depending on the kind and severity of hearing loss, using hearing aids has variable effects on auditory working memory. This study looked into the auditory working memory capacity after using hearing aids for more than 6 months.

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Brain tumors pose a significant threat to human health, require a precise and quick diagnosis for effective treatment. However, achieving high diagnostic accuracy with traditional methods remains challenging due to the complex nature of brain tumors. Recent advances in deep learning have showed potential in automating brain tumor classification using brain MRI images, offering the potential to enhance diagnostic result.

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Background: School refusal behaviour is an umbrella term that often subsumes constructs such as truancy, school refusal, and school phobia. It is influenced by various psychological and psychosocial factors and can lead to significant distress to the child and the family.

Aim: To assess the clinical and functional profile of school refusal behavior in children and adolescents presenting to a tertiary care child and adolescent psychiatry center in the Indian context.

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Background: Excessive alcohol use leads to a spectrum of liver disease. While physicians treat liver disease, the cause, i.e.

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Article Synopsis
  • Gestational diabetes mellitus (GDM) is typically treated with either metformin or insulin, but their effects on children's heart and metabolic health are not well understood.
  • The study aimed to compare the cardiometabolic outcomes in children of mothers treated with these two medications through a systematic review of randomized control trials published between 1974 and 2024.
  • Results showed that children whose mothers used metformin had better body composition and lower fasting glucose and triglyceride levels, but overall, most cardiometabolic outcomes did not differ significantly, indicating a need for further research with longer follow-ups and diverse populations.*
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A visible light-induced cycloaddition of 1,3-dienes and -quinonemethides through EDA complexation is reported. The reaction does not require any external photocatalyst, oxidant or additive. The generality of the method is established through a broad substrate scope.

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Purpose: To study the different subtypes of glaucoma and to analyze the demographic and clinical profile of glaucoma patients along with associated risk factors in a multi-locational North Indian study.

Methods: Newly diagnosed and known glaucoma patients on treatment were enrolled in the study. Complete history was taken, and clinical evaluation was done by senior glaucoma experts.

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  • Researchers focused on inhibiting Cbl-b, a protein that regulates T cell activation, to explore its therapeutic potential.
  • After screening a vast DNA-encoded library, they identified a promising compound that was confirmed through biochemical assays.
  • Optimization efforts were enhanced by obtaining a cocrystal structure, revealing how the compound binds to the SH2 domain of Cbl-b, although its effectiveness in cells was limited to high concentrations.
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Background: Depressive disorders are one of the most common psychiatric disorders that occur in people of all ages.

Aim: To assess the efficacy of cognitive behavior therapy (CBT) and interpersonal therapy (IPT) in cases of depression.

Materials And Methods: The sample for the study comprised 52 diagnosed cases of major depressive disorder (MDD) based on the 10 revision of the International Classification of Diseases (ICD-10) criteria in the age range of 21 to 50 years.

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  • Lyme borreliosis represents a significant public health issue in India, with limited understanding of its prevalence and insufficient data on its epidemiology, prompting a study in Sikkim and Arunachal Pradesh to assess seropositivity.
  • The study enrolled 793 participants and utilized the NovaLisa™ Lyme Borrelia IgG ELISA kit for qualitative detection of IgG antibodies, revealing a seroprevalence of 3.7%, with varying rates between the two states (4.1% in Arunachal Pradesh and 2.3% in Sikkim).
  • The findings indicate that Sikkim is a newly identified endemic area for Lyme disease, and no direct link was found between Lyme-related symptoms and Ig
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For any nation the health of its citizens especially that of the reproductive age women is critical and of paramount importance as they are the ones who usher in the new generation. Now that India is undergoing triple burden of malnutrition, if the pregnant woman is underweight, overweight, obese or diabetic both the mother and the baby are at a high risk of developing complications not only during pregnancy but also postpartum. Hence, having a good nutritional status is so important even before the woman conceives.

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The leaves of are used as an anthelmintic remedy by the tribal communities of upper Assam in India. The present study was carried out to validate the anthelmintic credentials of this plant. Mature and larval worms were exposed to varying concentration of methanolic leaf extract of plant and parasites were observed for paralysis and mortality.

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Dielectric ceramic capacitors are highly regarded for their rapid charge-discharge, high power density, and cyclability in various advanced applications. However, their relatively low energy storage density has prompted intensive research aiming at developing materials with a higher energy density. To enhance energy storage properties, research has focused on modifying ferroelectric materials to induce relaxor ferroelectricity.

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Article Synopsis
  • The Health and Demographic Surveillance System (HDSS) is a longitudinal study in India that tracks health and demographic changes across nearly 20 sites, covering a population of about 2 million.
  • The Indian HDSS Network (IHN) was established to enhance collaboration among 19 sites, aiming for standardized data collection while maintaining local autonomy to produce quality health data.
  • The IHN focuses on facilitating multicentric research, improving population health through evidence-based policymaking, and securing funding to enhance its operations and technology integration.
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Background And Aims: Postoperative pain for patients having hip arthroplasty ranges from moderate to severe. Many regional anaesthesia procedures treat postoperative pain to improve functional ability and quality of life. Evidence comparing the analgesic effects of the pericapsular nerve group (PENG) block and fascia iliaca compartment block (FICB) remains unclear.

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Background: Engineering students like any other students face several stressors in their lives, which make them vulnerable to depression. Depression may affect students' academic performance.

Aim: The present study aims to estimate the prevalence and associated risk factors of depression among engineering students.

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Human papillomavirus (HPV) is implicated in over 90% of cervical cancer cases, with factors like regional variability, HPV genotype, the population studied, HPV vaccination status, and anatomical sample collection location influencing the prevalence and pathology of HPV-induced cancer. HPV-16 and -18 are mainly responsible for the progression of several cancers, including cervix, anus, vagina, penis, vulva, and oropharynx. The oncogenic ability of HPV is not only sufficient for the progression of malignancy, but also for other tumor-generating steps required for the production of invasive cancer, such as coinfection with other viruses, lifestyle factors such as high parity, smoking, tobacco chewing, use of contraceptives for a long time, and immune responses such as stimulation of chronic stromal inflammation and immune deviation in the tumor microenvironment.

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Ayurveda is one of the ancient traditional medicine systems in India. However, several Ayurvedic medicines lack scientific evidence about their efficacy. This study reports the in vitro anthelmintic effects of three common Ayurvedic formulations, Krimimudgar Ras, Kriminol, and Birangasav on a poultry cestode sp.

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Background: Globally, hypertension is the leading risk factor for men and women and the largest contributor to premature deaths and diseases in India. Health literacy (HL) and health-care access are important determinants for self-care management of hypertension.

Objectives: The purpose of this study was to estimate the prevalence of HL, health-care access, and their importance in the self-care management of hypertension.

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Unlabelled: Head and neck squamous cell carcinomas (HNSCC) is one of the most prevalent type of cancer known in Indian population. Studies are needed to identify the early biomarkers for HNSCC. MicroRNAs (miRNAs) are non-coding RNA molecules, expression of which can be used as biomarker for early diagnosis of HNSCC.

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Article Synopsis
  • Cyclin-dependent kinases (CDKs) are crucial for regulating the cell cycle, and their alteration in cancer cells leads to uncontrolled growth, making CDK2 a promising target for anticancer drugs.
  • Researchers developed a series of selective small molecule inhibitors for CDK2, utilizing structure-based drug design to optimize potency and selectivity against other kinases like ERK2 and CDK4.
  • One specific compound showed impressive results, achieving a 112% tumor growth inhibition in mice with ovarian cancer (OVCAR3) when administered at a dosage of 50 mg/kg twice daily.
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With the increasing prevalence of anthelmintic resistance in animals recorded globally, and the threat of resistance in human helminths, the need for novel anthelmintic drugs is greater than ever. Most research aimed at discovering novel anthelmintic leads relies on high throughput screening (HTS) of large libraries of synthetic small molecules in industrial and academic settings in developed countries, even though it is the tropical countries that are most plagued by helminth infections. Tropical countries, however, have the advantage of possessing a rich flora that may yield natural products (NP) with promising anthelmintic activity.

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