Effect of dehydrozingerone, a half analog of curcumin on dexamethasone-delayed wound healing in albino rats.

Oxidative stress is triggered by the wound which results in the production of reactive oxygen species (ROS), thereby delaying normal wound repair. Therefore, it is important to reduce the level of ROS to improve healing. A known antioxidant, dehydrozingerone (DHZ) was synthesized and selected for the study.

Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds.

Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally inflicted wounds in rats.

Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University.

Results: Morin showed significant wound contraction on day 7 as compared to control with mean closure of 47.

Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats.

Unlabelled: ETHNO-PHARMACOLOGICAL RELEVANCE: The seeds of Sesamum indicum Linn. (Pedaliaceae) has been used traditionally for the treatment of wounds in Buldhana district of Maharashtra state. Sesamol is the main anti-oxidative constituent contained mainly in the processed sesame seed oil which has not been explored scientifically for its wound healing activity.