Publications by authors named "Arun Somasundaram"
Nail involvement in Langerhans cell histiocytosis is rarely reported in the literature. According to the reported cases, it is believed that the involvement of nails has a poor prognosis because of multisystem involvement. Performing a nail bed biopsy might be challenging for children.
View Article and Find Full Text PDFBackground/objectives: Weight loss outcomes vary individually. Magnetic resonance imaging (MRI)-based evaluation of adipose tissue (AT) might help to identify AT characteristics that predict AT loss. This study aimed to assess the impact of an 8-week low-calorie diet (LCD) on different AT depots and to identify predictors of short-term AT loss using MRI in adults with obesity.
View Article and Find Full Text PDFSex-specific abdominal organ volume and proton density fat fraction (PDFF) in people with obesity during a weight loss intervention was assessed with automated multiorgan segmentation of quantitative water-fat MRI. An nnU-Net architecture was employed for automatic segmentation of abdominal organs, including visceral and subcutaneous adipose tissue, liver, and psoas and erector spinae muscle, based on quantitative chemical shift-encoded MRI and using ground truth labels generated from participants of the Lifestyle Intervention (LION) study. Each organ's volume and fat content were examined in 127 participants (73 female and 54 male participants; body mass index, 30-39.
View Article and Find Full Text PDFArticle Synopsis
- Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a serious skin disorder that can lead to severe health complications in children and requires prompt management to prevent fatal outcomes.
- Treatment options are limited due to the few reported cases and lack of substantial research, making it challenging to find effective therapies.
- A case study of a five-year-old child with FUMHD and seizures showed that while multiple treatments were ineffective, a single infusion of low-dose intravenous immunoglobulin led to rapid improvement and disease control.
Background: Human brown adipose tissue (BAT), mostly located in the cervical/supraclavicular region, is a promising target in obesity treatment. Magnetic resonance imaging (MRI) allows for mapping the fat content quantitatively. However, due to the complex heterogeneous distribution of BAT, it has been difficult to establish a standardized segmentation routine based on magnetic resonance (MR) images.
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