Publications by authors named "Arun R Kaithi"
Pharmacopsychiatry
March 2022
Article Synopsis
- This international guideline suggests enhancing clozapine package inserts by implementing ancestry-based dosing and titration to reduce adverse drug reactions (ADRs).
- Clozapine, a powerful medication, has a narrow therapeutic range and is highly associated with toxicity, especially in certain populations; it is especially risky due to its high rates of pneumonia-related mortality.
- The guideline outlines six personalized dosing schedules based on ancestry and metabolic activity, recommending varying daily doses of clozapine tailored to individual patient profiles to minimize the risk of ADRs.
Indian J Psychol Med
January 2020
Article Synopsis
- Since 1997, studies show that Asians require lower doses of clozapine than Caucasians, with average doses in Asian countries being less than 300 mg/day.
- A systematic review from 2019 found that clozapine concentration-to-dose (C/D) ratios were significantly higher in East Asians (1.57) compared to Caucasians (1.07), highlighting the need for personalized dosing strategies.
- For Asian patients, the therapeutic dose for clinical response may range from 150 mg/day for female non-smokers to 300 mg/day for male smokers, with about 10% being genetic poor metabolizers needing very low doses of 50-150 mg/day.
