Patient-reported outcome measures following maxillomandibular advancement surgery in patients with obstructive sleep apnoea syndrome.

Maxillomandibular advancement (MMA) is an effective treatment for obstructive sleep apnoea syndrome (OSAS) that is refractory to conventional treatment. However, it is a highly invasive procedure with several recognised side effects, and we know of few data on its effect on important patient-reported outcome measures (PROMS). Here we describe a case series of patients selected for MMA through our joint respiratory/maxillofacial surgery clinic, detailing the effect of MMA on objective physiological measurements and important PROMS.

Long-Term Survival on Noninvasive Ventilation in Adults With Thoracic Scoliosis.

Background: Subjects with thoracic scoliosis were an important group in early studies of noninvasive ventilation (NIV). The aim of this study was to describe current rates of initiation of NIV and survival after initiation in this population.

Methods: This study included patients identified as having thoracic scoliosis and established between 1993 and 2018 on home NIV.

Correction of Paradoxical Ribcage Motion in Scoliosis by Noninvasive Ventilation.

Study Design: Observational study of ribcage motion in scoliosis.

Objective: To see whether noninvasive ventilation corrected paradoxical inward motion of the ribs during inspiration.

Summary Of Background Data: Paradoxical inward motion of the ribs is observed after rib fractures, low cervical cord injury, and in chronic obstructive pulmonary disease.

Bilateral calf chronic compartment syndrome in an elderly male: a case report.

Leg pain is a common presentation to the outpatient department. Bilateral calf chronic compartment syndrome is a rare cause of bilateral calf pain. Although this condition has been well documented in young athletes, it has rarely been reported in the elderly.

Hypernatremia secondary to soluble paracetamol use in an elderly man: a case report.

Introduction: Soluble (effervescent) paracetamol is routinely given to elderly patients for convenience. A daily dose of 4 gm in this soluble formulation can contain up to 8.7 gm of sodium chloride, which exceeds the threshold recommended by the World Health Organization.

What strategies to boost production of affordable fixed-dose anti-retroviral drug combinations for children in the developing world?

Background: No more than 8% of HIV positive children needing treatment in low- and middle-income countries have access to antiretroviral drugs (ARVs). Children presently account for about 4% of all treated patients, while for equitable access they should make up at least 13%.

Aims: This study explores key issues, implications and interaction dynamics to boost production of easy-to-use and affordable fixed-dose combination (FDC) ARVs for children in the developing world.

Pharmaceutical industry's corporate social responsibility towards HIV/AIDS.

The pharmaceutical industry has a corporate social responsibility (CSR) towards HIV/AIDS. Measures taken to increase awareness of HIV/AIDS, availability and accessibility of potent and patient-friendly FDCs / Kits for adults and children will go a long way in increasing awareness and acceptance of this disease and its therapy. This will improve adherence, lower resistance and facilitate better disease management.