Publications by authors named "Arun J"

As the amount and complexity of biomedical data continue to increase, machine learning methods are becoming a popular tool in creating prediction models for the underlying biomedical processes. Although all machine learning methods aim to fit models to data, the methodologies used can vary greatly and may seem daunting at first. A comprehensive review of various machine learning algorithms per biomedical applications is presented.

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Water pollution is the major problem seen in today's scenario and even pollutants at low concentration harms our environment. In industrial sector usage of phenol is seen even at low concentrations. The interaction of phenol in the environment provides adverse effects to living beings.

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Complexity of wastewater is the most challenging phenomenon on successful degradation of pollutant via any wastewater treatment regime. Upon availability of numerous techniques, Advanced Oxidation Processes (AOP) is the most promising technique for treating industrial wastewater. Higher operating cost is the most promising factor that possess challenge for the industrial scale usage of the AOP process.

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Article Synopsis
  • - Immunotherapy activates cancer patients' immune systems to identify and eliminate cancer cells, with checkpoint blockade therapy aiming to boost a suppressed immune response and improve treatment outcomes.
  • - The study examined the use of checkpoint inhibitors, CAR T cells, and vaccines together to enhance immunotherapy effectiveness, considering their potential to overcome immunosuppression in tumors.
  • - Despite promising results from preclinical tests targeting specific immune-regulatory proteins (like LAG3 and PD-1), challenges like drug side effects and tumor microenvironment issues still limit treatment success.
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Modernisation of industrial and transportation sector would have not imaginable without the help of fossil fuels, but constant usage has led to many environmental concerns. As a step forward, for safer next generation living we are forced to look into green fuels like bio‑hydrogen and higher alcohols. This review mainly focuses on bio‑hydrogen production via biological pathways, genetic improvements, knowledge gap, economics, and future directions.

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Bioremediation of heavy metals and dyes is one of the emerging techniques globally as it is evident from the numerous publications made by various research groups. Biofilm-assisted bioremediation is one of the trending approaches as it facilitates negatively charged extracellular polymeric substances which makes the bacteria resistant to the toxic chemicals. Genetic engineering of microbes will make them unique in the bioremediation process.

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Global pollution is calling for advanced methods to remove contaminants from water and wastewater, such as TiO-assisted photocatalysis.  The environmental applications of titanium dioxide have started after the initial TiO application for water splitting by Fujishima and Honda in 1972. TiO is now used for self-cleaning surfaces, air and water purification systems, microbial inactivation and selective organic conversion.

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Access to clean water has reduced in recent years due to pollution and man-made activities. Wastewater treatment regimens are many such as electrocoagulation, adsorption, ozonation, membrane and advanced oxidation processes. Owing to economical, resource availability and ease of operation adsorption has upper hand over all other methods employed in wastewater treatment.

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Food chain-based waste is generated in tonnes globally and this has led to release of greenhouse gases, poor air quality, land and water pollution. Food wastes are generated in tremendous quantity globally from local producer to international consumers and traders. Authors have used systematic literature review to identify the research gaps, thematic areas, methodology, sustainable techniques and future directions of processing food supply chain waste.

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The release and prevalence of organic pollutants in an aqueous environment due to industrial discharges, agricultural operations, or inappropriate waste disposal is a huge threat to attaining sustainable development. As a result, wastewater treatment has attained a huge scope as it is evident from the number of articles published in recent years. Among the various techniques, bioremediation is one of the economical and eco-friendly means of wastewater treatment for the removal of organic pollutants.

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In this study, a novel bio-refinery concept was designed for efficient utilization of de-oiled algae cake as bio-resource for biopolymer (Polyhydroxyalkanoates (PHB)) production and thereby making the biorefinery process more economical and sustainable by completely utilizing the algal biomass without the production of waste algal residues. Algal oil was extracted from Chlorella vulgaris biomass via Bligh and Dyer method for biodiesel production through parabolic solar trough collector. Maximum lipid yield was 27.

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Bioethanol is an eco-friendly green fuel, owing to its production from sustainable bio-based sources. In this study, bioethanol (BE) is produced from Kappaphycus alverezii reject (KR) blended with Solid Food Waste (SFW). This bioethanol is blended with petroleum-based diesel (PBD) in the following proportions: 15%, 20% and 25% for further studies.

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The process of removal of heavy metals is important due to their toxic effects on living organisms and undesirable anthropogenic effects. Conventional methods possess many irreconcilable disadvantages pertaining to cost and efficiency. As a result, the usage of biochar, which is produced as a by-product of biomass pyrolysis, has gained sizable traction in recent times for the removal of heavy metals.

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Excessive phosphate run-off with total phosphorus concentration greater than 20 μg P L triggers the growth of harmful algal species in waterbodies and potentially leads to eutrophication. This has severe negative implications on aquatic environment and impacts human health. The annual economic impact of harmful algal blooms is reported to be as high as $25 million for public health and commercial fishery sector, $29 million for recreation/tourism sector and $2 million for monitoring and management.

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Hydrothermal liquefaction (HTL) of biomass results in the formation of bio-oil, aqueous phase (HTL-AP), bio-char, and gaseous products. Safer disposal of HTL-AP is difficult on an industrial scale since it comprises low molecular acid compounds. This review provides a comprehensive note on the recent articles published on the effective usage of HTL-AP for the recovery of valuable compounds.

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The environmental impacts of persistent organic pollutants (POPs) is an increasingly prominent topic in the scientific community. POPs are stable chemicals that are accumulated in living beings and can act as endocrine disruptors or carcinogens on prolonged exposure. Although efforts have been taken to minimize or ban the use of certain POPs, their use is still widespread due to their importance in several industries.

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Environmental concerns due to fossil fuel usage has turned the research interest towards biomass and bioenergy field. Renewable biomass such as microalgae provides numerous advantages as they can grow in wastewater; sequester carbon dioxide, economical and eco-friendly. In this study, effect of pretreatment of microalgae (Scenedesmus obliquus) biomass using post-hydrothermal liquefaction wastewater (PHWW) for bio-oil production through hydrothermal liquefaction at a temperature of 300 °C was studied.

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Algae is abundantly present in our ecosystems and can be easily extracted and used for production of biopolymers. Algae does not produce any anthropogenic, harmful effects, has a good growth rate, and cultivable in wastewater. This literature elucidates the potential of algae biomass by comparing various seaweed and microalgae strains.

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Advancements in medical research has resulted in the modernization of healthcare facilities, subsequently leading to a higher level of production and usage of pharmaceuticals to sustain better quality of life. Pharmaceutical active compounds (PhACs) possess high genotoxicity and eco-toxicity thus presenting numerous side effects to living beings on long-term exposure. The fate and toxicity of PhACs were explored in detail, aiming to elucidate their occurrence and transmission in wastewater treatment systems (WWTPs).

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Thermostable enzymes are a field of growing interest in bioremediation, pharmaceuticals, food industry etc., due to their ability to catalyze bio reactions at high temperatures. This review aims to provide an overview on extremophiles with a special focus on thermophiles and enzymes produced from extremophilic bacteria.

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In this study, hydrothermal liquefaction of household waste was performed to produce valuable liquid hydrocarbons with aqueous phase as by-product. Photocatalytic reforming of aqueous phase was carried out for hydrogen production. Liquefaction of 15 g waste at temperature of 320 °C and solvent to biomass ratio of 13.

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In rural India, unpleasant atmosphere, anthropogenic gas emission, air and soil pollution are caused due to disposal of livestock's wastes (cow dung and chicken waste) in open environment. This study provides zero emission concept for waste disposal and value addition of these wastes for renewable green energy production. In this study, biogas production was carried out with varying proportion of cow dung to chicken waste (1:0, 0:1, 1:1, 2:1, 1:2, 3:1 and 1:3) for duration of 40 days.

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Algae a promising energy reserve due to its adaptability, cheap source, sustainability and it's growth ability in wastewater with efficient sequestration of industrial carbon dioxide. This review summarizes the pathways available for biofuel production from carbon sequestered algae biomass. In this regard, this review focuses on microalgae and its cultivation in wastewater with CO sequestration.

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The objective of this work was to study the hydrothermal liquefaction (HTL) of Prosopis juliflora biomass for the production of ferulic acid and bio-oil. Biomass was processed with various solvents (NaOH, KOH, HCl and HSO) to produce ferulic acid (FA). FA oxidation was carried out using the Nano ZnO catalyst to produce an optimum vanillin yield of 0.

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The present work endeavors to report a systematic approach of developing the lipidic self-nanoemulsifying formulation of olmesartan medoxomil (OMT) on the principles of Quality by Design (QbD). For preparing the self-nanoemulsifying formulation, a mixture of oil, surfactant and cosurfactant were used as vehicles. The excipients were selected after screening by solubility as well as pseudoternary phase titration studies.

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