Publications by authors named "Arun Ganesh"
Article Synopsis
- A study evaluated the effectiveness of stellate ganglion block (SGB) as a treatment for refractory ventricular arrhythmias, focusing on patient characteristics and success predictors.
- The analysis involved 117 patients from the Czech Republic and the US, with results showing that age negatively impacted SGB success, while a higher left ventricular ejection fraction hinted at improved outcomes.
- Overall, SGB was effective across different types of arrhythmias and cardiomyopathy causes, but elderly patients saw less benefit in arrhythmia suppression within 24 hours post-treatment.
Background: Ventricular tachycardia (VT) and ventricular fibrillation (VF) are life-threatening conditions and can be refractory to conventional drug and device interventions. Stellate ganglion blockade (SGB) has been described as an adjunct, temporizing intervention in patients with refractory ventricular arrhythmia. We examined the association of SGB with VT/VF in a multicenter registry.
View Article and Find Full Text PDFBackground Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circulation, supporting evidence is limited. We examined changes in venous capacitance surrogates pre- and post-SNM.
View Article and Find Full Text PDFObjectives: The authors estimated changes of stressed blood volume (SBV) induced by splanchnic nerve block (SNB) in patients with either decompensated or ambulatory heart failure with reduced ejection fraction (HFrEF).
Background: The splanchnic vascular capacity is a major determinant of the SBV, which in turn determines cardiac filling pressures and may be modifiable through SNB.
Methods: We analyzed data from 2 prospective, single-arm clinical studies in decompensated HFrEF (splanchnic HF-1; resting hemodynamics) and ambulatory heart failure (splanchnic HF-2; exercise hemodynamics).
Article Synopsis
- The review discusses the use of stellate ganglion blockade (SGB) as a treatment for patients with severe ventricular arrhythmias that don't respond to other therapies.
- SGB can significantly reduce the frequency of arrhythmias and defibrillation events for 24-72 hours, providing a critical window for additional treatments like catheter ablation or heart surgery.
- The procedure is shown to be safe, even in patients on anticoagulants, and is effective across different types and causes of ventricular arrhythmias.
Objectives: We hypothesized that splanchnic nerve blockade (SNB) would attenuate increased exercise-induced cardiac filling pressures in patients with chronic HF.
Background: Chronic heart failure (HF) is characterized by limited exercise capacity driven in part by an excessive elevation of cardiac filling pressures.
Methods: This is a prospective, open-label, single-arm interventional study in chronic HF patients.
Article Synopsis
- This study aimed to establish a neurocardiology service to offer autonomic modulation as a treatment for treatment-refractory ventricular arrhythmias (VAs).
- The research involved 20 patients undergoing temporary stellate ganglion blockade (SGB) and found significant reductions in VA episodes and defibrillation events within 24 and 48 hours post-procedure.
- Results showed that SGB was safe and effective, with 45% of patients experiencing no recurrence of ventricular tachycardia (VT) or ventricular fibrillation (VF) after treatment.
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View Article and Find Full Text PDFIntroduction: Treatment refractory ventricular arrhythmias (VAs) are often driven and exacerbated by heightened sympathetic tone. We aim to conduct a systematic review and meta-analysis of published studies of a temporary percutaneous stellate ganglion block (SGB) on VA burden and defibrillation episodes in patients with treatment refractory VAs.
Methods: Relevant studies from January 1960 through May 2017 were identified in PubMed and Google Scholar.