Publications by authors named "Arun Flynn"
Article Synopsis
- Symmetric dimethylarginine (SDMA) is a by-product of cellular metabolism linked to endothelial dysfunction and vascular risk, challenging its previously considered inert status.
- The review focuses on SDMA's role in cerebrovascular diseases, particularly ischaemic stroke, examining its impact on factors like nitric oxide signaling, inflammation, and oxidative stress.
- Recent studies indicate a correlation between elevated SDMA levels and poor outcomes in stroke patients, emphasizing the need for further research to understand SDMA's potential as both a marker and mediator of cerebrovascular disease.
Uromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have demonstrated an association between UMOD risk variants and hypertension. We aimed to dissect the role of dietary salt in renal UMOD excretion in normotension and chronic hypertension.
View Article and Find Full Text PDFPreexisting or new onset of hypertension affects pregnancy and is one of the leading causes of maternal and fetal morbidity and mortality. In certain cases, it also leads to long-term maternal cardiovascular complications. The placenta is a key player in the pathogenesis of complicated hypertensive pregnancies, however the pathomechanisms leading to an abnormal placenta are poorly understood.
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