Publications by authors named "Arun A Chandrakumar"
Rab11 GTPase proteins are required for cytokinesis, ciliogenesis, and lumenogenesis. Rab11a is critical for apical delivery of podocalyxin (PODXL) during lumen formation in epithelial cells. SH3BP5 and SH3BP5L are guanine nucleotide exchange factors (GEFs) for Rab11.
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- The PAR-1-MARK pathway regulates cell polarity by phosphorylating microtubule-associated proteins, specifically ARHGEF2.
- Liver kinase B1 (LKB1) activates MARK3, leading to the phosphorylation of ARHGEF2, which disrupts its binding to DYNLT1 and promotes RHOA activation.
- This phosphorylation is crucial for forming stress fibers and maintaining organized cellular structures, highlighting a regulatory mechanism that connects microtubules and the actin cytoskeleton in epithelial cells.