Synthesis of diversely substituted quinazoline-2,4(1,3)-diones by cyclization of -butyl (2-cyanoaryl)carbamates.

The synthesis of diversely substituted quinazoline-2,4(1,3)-diones by cyclization of -butyl (2-cyanoaryl)carbamates using readily accessible Boc protected -amino nitriles is reported. The reaction proceeds smoothly at room temperature using 1 equiv. of HO under basic conditions.

Biofilm in Endodontic Infection and its Advanced Therapeutic Options - An Updated Review.

Pulpal and periapical pathosis are biofilm-induced infections. Understanding the complex nature of endodontic biofilm would help to create a new disinfection strategy to eliminate the microorganism from the root canal system. The intricate canal structure creates challenges for proper disinfection, necessitating the need to understand the biofilm structure, composition, and mechanism within the biofilm community.

Evaluation of Compressive and Flexural Strengths of Two Resin-based Core Materials with an Alkasite Material: An Study.

Aim: To compare and evaluate the compressive and flexural strengths of two resin-based core build-up materials with an alkasite material.

Materials And Methods: ParaCore, Tetric N ceram Bulk-fill composite, and Cention N were used. A total of 90 specimens were prepared.

Novel Management of Hypersensitive Dentin Using Propolis-based Herbal Desensitizing Agents: An Scanning Electron Microscopic Study.

Aim: The objective of this study was to assess the efficacy of novel propolis-based varnish against the two conventional varnishes on quantitative and qualitative assessments of occlusion of dentin tubules and resistance to erosive and abrasive wears employing scanning electron microscope (SEM).

Methods: Thirty human premolars free from caries extracted due to orthodontic reasons were included in the study. Experimental group was done based on treatment received and divided into three groups.

Establishment of (Dennst.) Alston inoculated with beneficial microbes in barren laterite rocks.

Developing countries including India are using laterite bricks extracted from laterite rocks for building construction. Laterite rocks are found barren usually as they are not fit for cultivation. Extraction of laterite bricks from these barren laterite rocks causing land degradation and posing environmental threats in the laterite excavated lands.

Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.

Hepsin, a type II transmembrane serine protease, is upregulated in prostate cancer and known to be involved in the progression of metastasis. Here we report a structure-guided approach, which resulted in the discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective inhibitors of hepsin. Potent and selective inhibition of hepsin by compound 8 is likely due to interactions of the amidine group at the S1 site with the cyclohexyl ring from the 2-aryl group projecting towards the S1' site and the tert-hydroxyl group interacting with His57 side-chain as revealed by X-ray crystallography.

Use of Frankia and actinorhizal plants for degraded lands reclamation.

Degraded lands are defined by soils that have lost primary productivity due to abiotic or biotic stresses. Among the abiotic stresses, drought, salinity, and heavy metals are the main threats in tropical areas. These stresses affect plant growth and reduce their productivity.

Protective effects of D-limonene on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rats.

The aim of this study was to evaluate the protective effects of D-limonene on the levels of lipid peroxidation by-products and antioxidant defence systems in the plasma and tissues of normal and streptozotocin (STZ)-induced diabetes rats. The experimental diabetes was induced in rats by a single dose of STZ (40 mg/kg i.p.

Ferulic acid, a dietary phenolic acid, modulates radiation effects in Swiss albino mice.

The radioprotective efficacy of Ferulic acid (FA) against whole body gamma radiation was studied in Swiss albino mice. To study the radiation protection, mice were administered with ferulic acid intraperitoneally (i.p) (50 mg/kg body weight.