Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3)-quinazolinones 3-substituted.

A novel series of 6-iodo-2-methylquinazolin-4-(3)-one derivatives, 3a-n, were synthesized and evaluated for their cytotoxic activity. Compounds 3a, 3b, 3d, 3e, and 3h showed remarkable cytotoxic activity on specific human cancer cell lines when compared to the anti-cancer drug, paclitaxel. Compound 3a was found to be particularly effective on promyelocytic leukaemia HL60 and non-Hodgkin lymphoma U937, with IC values of 21 and 30 μM, respectively.