Publications by authors named "Arturo Panduro"
Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with obesity and other cardiometabolic risk factors. MASLD has rapidly become the most common cause of liver disease worldwide, currently affecting 38% of the global population. Excess weight causes chronic inflammation and the activation of different pathways involved in liver damage.
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- Viral hepatitis (A-E) is a significant global health issue, prompting the WHO to launch a 2015 initiative aimed at drastically reducing infections and deaths by 2030, especially in countries like Mexico which is among the 38 focus nations.
- In Mexico, while there are established programs for diagnosing and treating hepatitis B and C, there is a lack of routine diagnosis for hepatitis D and E, and the National Hepatitis C Elimination Program started in 2020 has not expanded to cover hepatitis B and E.
- Efforts to control viral hepatitis in Mexico need more resources, improved diagnosis and vaccination for hepatitis A and B, treatment coverage for hepatitis B and C, and collaboration across different sectors to enhance patient care.
Article Synopsis
- - The study investigates the risk factors for Hepatitis C Virus (HCV) transmission, focusing on subtype 1a in Mexico, where it was found to be the most prevalent (58.5%) among the 260 infected adults analyzed between 2014 and 2018.
- - Significant risk factors associated with HCV transmission include intravenous drug use and tattoos for subtypes 1a and 3a, while hemodialysis and blood transfusions are linked to subtype 1b.
- - The research suggests subtype 1a was introduced to Mexico in 1976, with notable increases in cases from 1998 to 2006, highlighting the need for tailored prevention strategies like improving medical training, reducing
Article Synopsis
- - The study examined the prevalence and risk factors of hepatitis C virus (HCV) among 294 HIV patients in West Mexico, finding that 36.4% were co-infected, with injection drug use being the most significant risk factor.
- - Various noninvasive methods were used to assess liver fibrosis, revealing that nearly half of the co-infected patients (47.7%) had advanced liver fibrosis, particularly those with HCV subtype 1a.
- - The research underscores the importance of understanding HCV's impact on the liver health of HIV patients in Mexico, indicating a need for targeted prevention strategies within this vulnerable group.
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- * Advances in Genomic Medicine and Nutrition reveal variations in genetic and lifestyle risks for chronic liver disease across different countries, paving the way for Personalized Medicine and Nutrition (PerMed-Nut) approaches.
- * Mexico's diverse ancestral background necessitates the development of a PerMed-Nut model addressing specific liver-related diseases, alongside improved training for health professionals in genomic hepatology to enhance prevention efforts.
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- The hepatitis B virus (HBV) poses a significant global health threat, and the World Health Organization aims for its elimination by 2030, although many countries, especially in Latin America, are struggling with this goal.
- A comprehensive review analyzed data on HBV genotype H (unique to Mexico) over the past 50 years, gathering information from 91 articles to cover topics like prevalence, risk factors, and clinical characteristics.
- To effectively tackle HBV infections in Mexico, it is vital to enhance training and awareness, improve diagnostics and prevention efforts, and foster collaboration among government health agencies, researchers, and the community.
Article Synopsis
- - Hepatitis B virus (HBV) poses a significant global health threat, causing a wide range of liver-related diseases from acute hepatitis to chronic conditions like cirrhosis and hepatocellular carcinoma (HCC), affecting millions annually.
- - The review highlights unique geographical patterns of HBV genotypes and their association with various clinical outcomes, as well as the role of host genetics, particularly single nucleotide polymorphisms (SNPs), in disease progression and response.
- - Key interactions between HBV and the host's immune and metabolic systems influence disease severity and outcomes, suggesting the need for tailored prevention strategies based on local characteristics and patient genetics.
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- This study investigates the prevalence of antiviral resistance and escape mutations in hepatitis B virus (HBV) infections in Mexico, focusing on various antiviral drugs including Lamivudine and Tenofovir.
- In a sample of 158 patients, the most common HBV genotype found was H (68.4%), with a notable 8.2% prevalence of resistance mutations, primarily the combined mutation rt180M+rt204V.
- Results point to the highest prevalence of resistance and escape mutations in genotypes A2 and H, marking an early detection of multidrug resistance cases in the region.
Article Synopsis
- Hepatitis B virus (HBV) is found globally and has ten genotypes, with genotype H being prominent in Mexico and possibly originating there, particularly among indigenous populations.
- The study aimed to determine the age of HBV genotype H in Mexico using molecular dating techniques, analyzing 92 sequences, including 48 from genotype H.
- Results estimated genotype H in Mexico to be around 2070.9 years old, with four significant diversification events identified, and confirmed the divergence of genotype H from genotype F approximately 8140.8 years ago.
Obesity is a risk factor for developing nonalcoholic fatty liver disease (NAFLD), and the associated molecular mechanisms could be targeted with nutrient-based strategies. Therefore, it is necessary to review the current mechanisms to propose further treatments. Obesity facilitates the onset of insulin resistance, lipidic abnormalities, hepatic fat accumulation, lipid peroxidation, mitochondrial dysfunction, excessive reactive oxygen species (ROS) production, and inflammation, all related to further steatosis progression and fibrosis.
View Article and Find Full Text PDFThe hypertriglyceridemic waist (HTGW) phenotype is characterized by concomitant increases in waist circumference (WC) and blood triglyceride levels (TG), which have been identified as a predictor of metabolic disorders. This study aimed to analyze associations between food consumption, exercise, and the gene rs1761667 G>A polymorphism with the HTGW phenotype in adult Mexicans. This cross-sectional study included a total of 255 participants (both genders, between 18-64 years of age).
View Article and Find Full Text PDFBackground: Dyslipidemias are metabolic abnormalities associated with chronic diseases caused by genetic and environmental factors. The Mexican population displays regional differences according to ethnicity with an impact on the type of dyslipidemia.
Aim: To define the main dyslipidemias, the frequency of lipid-related risk alleles, and their association with hyperlipidemic states among different ethnic groups in West Mexico.
Article Synopsis
- Traditional diets, like the Mediterranean and traditional Mexican diets, are beneficial, but Italian and Mexican women are increasingly moving away from these eating patterns.
- A study analyzed the dietary patterns of 811 Italian women and 215 Mexican women, finding distinct patterns: Italian women consumed more legumes and vegetables or processed snacks, while Mexican women had a mix of meats and processed foods versus fruits and whole grains.
- Healthier dietary patterns were linked to better nutrient quality, but younger women were more likely to adopt less healthy Western-style diets, highlighting the need to promote traditional diets to younger generations.
Viral Kinetics of an Acute Hepatitis B Virus Subgenotype F1b Infection in a Mexican Subject.
Clin Liver Dis (Hoboken)
February 2022
Content available: Author Interview and Audio Recording.
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- The GENOMEX diet focuses on using genetics to help prevent and manage obesity, particularly in individuals with risk factors for weight-related diseases.
- A study with 28 participants over six months examined how this diet affected their emotions, self-efficacy, and unhealthy eating behaviors, revealing a significant link between mood and unhealthy eating choices.
- The intervention led to a reduction in negative emotions and unhealthy eating, with a slight increase in self-efficacy among participants, suggesting that a diet aligned with cultural and genetic factors can positively influence weight management.
Article Synopsis
- Viral hepatitis poses a significant health challenge globally, particularly affecting low-income individuals, and this study focused on its prevalence, along with HIV and liver damage, in a public hospital in West Mexico.
- Through a retrospective analysis of over 10,000 patients, the study found that 3.9% had hepatitis C, 1.0% had hepatitis B, and 2.9% had HIV, with many patients exhibiting abnormal liver enzyme levels.
- The study concluded that there is a high rate of viral infections and liver fibrosis among these populations, highlighting the need for ongoing testing and early intervention strategies to reduce the disease burden.
Article Synopsis
- The study focuses on hepatitis B virus (HBV) genotypes F and H, which are more prevalent in the Americas, specifically Brazil and Mexico.
- Researchers sequenced the complete genomes of 90 plasma samples with detectable HBV DNA using three different amplification methodologies and bioinformatics tools for analysis.
- Results showed successful sequencing of 18 samples, identifying key genetic variants in preS, S genes, and mutations in the precore/core region, which can inform clinical and epidemiological research on hepatitis B in Latin America.
Hepatitis C virus (HCV) infection is influenced by genetic (e.g., polymorphisms) and environmental factors between the virus and the host.
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