Publications by authors named "Arturo Otamendi"
Early prognostic information in cases of severe spinal cord injury can aid treatment planning and stratification for clinical trials. Analysis of intraparenchymal signal change on magnetic resonance imaging has been suggested to inform outcome prediction in traumatic spinal cord injury. We hypothesized that intraparenchymal T-weighted hypointensity would be associated with a lower potential for functional recovery and a higher risk of progressive neurological deterioration in dogs with acute, severe, naturally occurring spinal cord injury.
View Article and Find Full Text PDFArticle Synopsis
- Vertebral osteosarcoma (OSA) is the most common primary bone tumor in dogs, and this study evaluated the survival rates of dogs treated with palliative decompressive surgery alone, or in combination with adjunctive treatments like radiation and chemotherapy.
- The research involved 22 client-owned dogs, revealing that those treated with surgery alone had a median survival of 42 days, while those treated with surgery and chemotherapy had a median of 82 days, and those receiving surgery, radiation, and chemotherapy had a significantly better median survival of 261 days.
- The study concluded that combining definitive radiation therapy and possibly chemotherapy with palliative decompressive surgery may considerably enhance survival in these dogs, suggesting that this approach could be the preferred treatment
Background: Extended-release levetiracetam (LEV-XR) has gained acceptance as an antiepileptic drug in dogs. No studies have evaluated its disposition in dogs with epilepsy.
Hypothesis/objectives: To evaluate the pharmacokinetics of LEV-XR in epileptic dogs when administered alone or with phenobarbital or zonisamide.
Aims: This study sought to investigate the effects of physical detraining on blood pressure (BP) and cardiac morphology and function in hypertension, and on pro- and anti-inflammatory cytokines (PICs and AIC) and oxidative stress within the brain of hypertensive rats.
Methods And Results: Hypertension was induced in male Sprague-Dawley rats by delivering AngiotensinII for 42 days using implanted osmotic minipumps. Rats were randomized into sedentary, trained, and detrained groups.