Publications by authors named "Arturo Ortiz-Alvarez"
Standardization and validation of a novel UPLC-MS/MS method to quantify first line anti-tuberculosis drugs in plasma and dried blood spots.
J Chromatogr B Analyt Technol Biomed Life Sci
August 2023
Tuberculosis (TB) is a high-burden infectious disease with high prevalence and mortality rates. The first-line anti-TB drugs include isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB). At present, the standard method of blood sampling for therapeutic drug monitoring (TDM) analysis is venipuncture.
View Article and Find Full Text PDFObjective: To evaluate the predictive performance of population pharmacokinetic models for piperacillin (PIP) available in the software MwPharm, TDMx and ID-ODs for initial dosing selection and therapeutic drug monitoring (TDM) purposes.
Methods: This is a prospective observational study in adult patients with severe infections receiving PIP treatment. Plasma concentrations were quantified by ultra-high performance liquid chromatography coupled to tandem mass spectrometry.
Background: Early surgical procedures on patients with infective endocarditis (IE) have shown a clearly benefit to reduce embolization at the central nervous system. We conducted a retrospective cohort in Mexican population to evaluate mortality and clinical outcomes in patients with IE with or without surgical intervention.
Objectives: Our aim was to evaluate factors associated with mortality in patients with IE and compare both groups with and without a surgical intervention.
The aim of this study was to develop a population pharmacokinetic model of rifampicin (RMP) in Mexican patients with tuberculosis (TB) to evaluate the influence of anthropometric and clinical covariates, as well as genotypic variants associated with MDR1 and OATP1B1 transporters. A prospective study approved by Research Ethics Committee was performed at Hospital Central in San Luis Potosí, Mexico. TB patients under DOTS scheme and who signed informed consent were consecutively included.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a pharmacokinetic model for isoniazid in Mexican tuberculosis patients, taking into account the genetic variability in the N-acetyltransferase-2 enzyme that affects drug metabolism.
- It involved measuring isoniazid plasma concentrations in 69 patients and using genetic data to consider different acetylator phenotypes, leading to varying drug clearance rates.
- The resulting model provides a validated method for determining initial dosing regimens of isoniazid tailored to individual metabolic profiles.
Article Synopsis
- * A total of 63 patients were monitored, and the research used a modeling technique to estimate how amikacin is cleared and distributed in the body, revealing that kidney function and ideal body weight significantly affect these parameters.
- * The final model provided specific dosing recommendations and showed that there is a considerable variability in how different patients metabolize amikacin, indicating a need for tailored dosing especially for those with high kidney clearance rates.
Article Synopsis
- Tuberculosis (TB) is a serious global health issue, requiring a 6-month treatment with rifampicin and isoniazid to reduce transmission and prevent complications.
- Low levels of these medications in the body can lead to longer treatment times and higher chances of treatment failure, necessitating the identification of patient characteristics that influence drug levels.
- A study involving 34 TB patients analyzed how factors like age, weight, and genetic variations affect the plasma concentrations of these drugs, finding that sex, dose/weight, and specific genetic markers play a significant role.
Introduction: Outpatient parenteral antimicrobial therapy is a safe, effective, and convenient way of administering antimicrobials for a wide variety of infections. So far there are no reports on the efficacy of outpatient antimicrobial therapy in Mexico. Our objective was to determine the outcomes, safety, and cost of outpatient ertapenem therapy (OET) in our hospital.
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