Publications by authors named "Arturo Casimiro-Ramos"
Comparative Genomics of the First Resistant Strain Isolated in Mexico: Phylogenomic and Pan-Genomic Analysis and Mutations Associated with Antifungal Resistance.
Arturo Casimiro-Ramos Celia Bautista-Crescencio Alvaro Vidal-Montiel Gloria M González Juan Alfredo Hernández-García
J Fungi (Basel)
May 2024
Article Synopsis
- * The genome consists of 12.86 Mbp, 70 contigs, and houses 5,432 genes, revealing that the strain belongs to clade IV, which is primarily found in South America.
- * A mutation linked to drug resistance was found in a key gene, which could help in developing new antifungal therapies and understanding drug resistance in fungi.
There is an urgent need to develop new antifungals due to the increasing prevalence of multidrug-resistant fungal infections and the recent emergence of COVID-19-associated candidiasis. A good study model for evaluating new antifungal compounds is , an opportunistic fungal pathogen with intrinsic resistance to azoles (the most common clinical drugs for treating fungal infections). The aim of the current contribution was to conduct tests of antifungal metabolites produced by the bacteria Q, identify their molecular structures, and utilize several techniques to provide evidence of their therapeutic target.
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- Candida haemulonii is a multi-resistant yeast that can be misidentified, making timely DNA-based identification and antifungal susceptibility testing crucial for effective treatment.
- A case involving a pediatric patient in Mexico City showed that caspofungin effectively treated a bloodstream infection caused by this yeast after accurate identification through molecular techniques.
- The study emphasizes the importance of quickly identifying C. haemulonii as a significant opportunistic pathogen related to C. auris, which can enhance understanding of its epidemiology and improve patient outcomes.