Publications by authors named "Arturo A Andrade"
Article Synopsis
- Alzheimer's disease is associated with impaired proteostasis, and enhancing it might help delay cognitive decline.
- KPT-330 (Selinexor), an XPO1 inhibitor, shows promise in improving proteostasis and enhancing autophagy in neurons, leading to better memory in Alzheimer's models.
- While KPT-330 increased overall amyloid deposition in the brain, it also resulted in lower levels of amyloid in specific areas like the thalamus, indicating that its effects on proteostasis and amyloid formation are region-specific.
