Oxidative stress is associated with cell death, wall degradation, and increased risk of rupture of the intracranial aneurysm wall.

Background: The cause of rupture of intracranial aneurysms (IA) is not well understood. We previously demonstrated that loss of cells from the IA wall is associated with wall degeneration and rupture.

Objective: To investigate the mechanisms mediating cell death in the IA wall.