Publications by authors named "Arti Yadav"

A comparative analysis of hair evidence recovered from the crime scene and the hair of suspects or victims is common in the forensic scenario. However, its evidentiary value increases with cosmetic applications like gel, wax, spray, or other hair treatments. Therefore, after extracting these products from hair strands, they can link the victim and accused to the crime scene and with each other, serving as corroborative evidence.

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Article Synopsis
  • The study investigates the properties of hydrochlorothiazide (HCTZ) after it is cocrystallized with 4-aminobenzoic acid (4-ABA), focusing on how this combination alters physical and chemical characteristics.
  • Techniques like infrared (IR) and Raman spectroscopy, along with quantum chemical methods, were used to analyze hydrogen bonding interactions and chemical reactivity, determining that B3LYP provides the most reliable results for spectroscopy.
  • The findings suggest that the cocrystal HCTZ-4ABA has enhanced chemical reactivity and softer properties compared to HCTZ alone, indicating that cocrystallization could improve a drug's physicochemical properties without affecting its therapeutic effects.
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Fingernails can act as important forensic evidence as they can be a source of DNA that may link the victim or accused to the crime scene and may also contain traces of drugs such as cocaine and heroin, in regular users. Moreover, previous studies have shown that analyzing fingernails with various techniques can reveal important information, such as age and sex. In this work, ATR-FTIR spectroscopy with chemometric tools has been used to estimate the age and sex from fingernails by analyzing 140 fingernail samples (70 males, and 70 females) collected from volunteers aged between 10 and 70 years old.

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Given the need, both academic and industrial, for new approaches and technologies for chiral discrimination of enantiomers, the present work demonstrates the development through rational design and integration of two new chiral platforms (molecular and membranous) for enantioselective recognition through visual as well as microscopic observation. The molecular platform () is based on the tryptophan derivative developed through the condensation of two tryptophan units with terepthaloyl chloride. While based on l-tryptophan recognizes -mandelic acid over the -isomer, the host with reverse chirality () recognizes S-mandelic acid over -isomer.

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Research on amino acids is an attractive area because of their application in metabolism, cancer treatment, growth, and repair of body tissue, and RNA and DNA syntheses. Twenty amino acids are primarily responsible for protein synthesis. In our study, we used a Cu nanocluster as an amino acid detector.

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Objectives: To study the effect of postmeal Fast-acting insulin Aspart (Fiasp) on the frequency of hypoglycemia compared to premeal injection among preschool children with type 1 diabetes.

Methods: A single-center trial was conducted among 65 pre-school children (6 mo to 6 y) with Type 1 diabetes for at least 6 mo, on multiple daily insulin injections. Children were randomized to receive their meal bolus postmeal or premeal for the first 3 mo, followed by cross-over at 3 mo.

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Depleting fossil fuels and net carbon emissions associated with their burning have driven the need to find alternative energy sources. Biofuels are near-perfect candidates for alternative energy sources as they are renewable and account for no net CO emissions. However, biofuel production must overcome various challenges to compete with conventional fuels.

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Lip balm may be encountered as physical evidence in cases involving sexual assaults, homicides, and kidnappings. Lip balm can be used as corroborative evidence by providing a potential link between the victim, accused, and the crime scene. For lip balms to be used as evidence, it is important to understand the diversity and their aging process under different conditions.

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Article Synopsis
  • The study focuses on the discotic liquid crystal DLC A8, examining its structural changes during various phase transitions using quantum chemical methods and vibrational spectroscopy.
  • It identifies four distinct phases: Iso, Discotic nematic, Columnar, and Crystalline, with specific mesophases observed during heating and cooling cycles through techniques like differential scanning calorimetry (DSC) and polarized optical microscopy (POM).
  • The research also employs density functional theory (DFT) and vibrational spectroscopic analysis to confirm molecular stability and elucidate the role of intermolecular hydrogen bonding throughout these transitions.
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Neonatal diabetes mellitus (NDM) is characterised by onset of persistent hyperglycaemia within the first 6 months of life. NDM is frequently caused by a mutation in a single gene affecting pancreatic beta cell function. We report an infant, born to a non-consanguineous couple, who presented with osmotic symptoms and diabetic ketoacidosis.

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Graphene is fundamentally a two-dimensional material with extraordinary optical, thermal, mechanical, and electrical characteristics. It has a versatile surface chemistry and large surface area. It is a carbon nanomaterial, which comprises sp hybridized carbon atoms placed in a hexagonal lattice with one-atom thickness, giving it a two-dimensional structure.

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Hydrochlorothiazide (HCTZ) being a diuretic drug widely used in anti-hypertensive therapy as it lowers the blood pressure by reducing the reabsorption of electrolytes in kidney resulting an increment of urine output and lowering the blood pressure. The purpose of the present work is to study the structural, vibrational and chemical properties of HCTZ based on its monomeric, dimeric and trimeric models by utilizing computational methods and experimental techniques. Density functional theory (DFT) with functional B3LYP and 6-311++G (d, p) basis set was used for a detailed computational study.

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Introduction: Optimal glycaemic control is essential for the prevention of future micro- and macrovascular complications in type 1 diabetes (T1D). The type of insulin, the type of insulin delivery device, the caregiver's knowledge, the patient's age, duration of diabetes, and self-monitoring of blood glucose affect glycaemic control in type 1 diabetes. In the present study, we analysed glycaemic control and factors affecting it at a tertiary care centre in northern India.

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Steroid-induced psychosis is a known serious adverse effect seen commonly in adults but less commonly in children. We present a seven-year-old girl with steroid-dependent nephrotic syndrome who developed abnormal behaviour, trichotillomania, alopecia and mood changes. She was investigated to rule out other causes and treated with tapering steroids, fluoxetine and olanzapine.

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Mauriac syndrome is rare; we share our experience of nine patients who presented at a young age with malnutrition, short stature, abdominal distention and deranged liver function.

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There have been concerted efforts toward cataloging rare and deleterious variants in different world populations using high-throughput genotyping and sequencing-based methods. The Indian population is underrepresented or its information with respect to clinically relevant variants is sparse in public data sets. The aim of this study was to estimate the burden of monogenic disease-causing variants in Indian populations.

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This study assessed potential of plant growth promoting rhizobacteria (PGPR) found in 34 soil samples collected from Sirmaur, Himachal Pradesh. Out of 238 rhizobacterial isolates, 48 rhizobacterial isolates exhibited multiple PGP (plant growth promoting) traits. Out of the 48 isolates, nine isolates exhibiting most promising PGP traits were evaluated.

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A set of 90 Indian soybean landraces were analysed for polymorphism at 43 SSRs and five allele specific markers of four major genes involved in regulating flowering and photoperiod response. A total of 42 polymorphic SSRs had amplified 126 alleles which served as raw data for estimation of genetic relationship and population structure among 90 accessions. Rare alleles of four and three SSRs were detected in accessions IC18768 and IC15089, respectively.

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Metallic nanowire networks are emerging as potential replacements for transparent conducting oxide coatings because of their high conductivity, flexibility and relative transparency. However, a cheap, reliable and controlled manufacturing process is required to exploit this and the surface of the copper nanowire needs to be protected if high conductivity is to be retained. In this study a fabrication method for highly aligned and densely packed copper nanowires with controlled length using pulse-electrodeposition and a nanoporous alumina template has been developed.

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Aims: Long-term treatment of Isoniazid (INH) in tuberculosis (TB) patients can lead to anti-tuberculosis drug-induced hepatotoxicity. To understand the mechanism of hepatotoxicity, an attempt has been made to elucidate the role of Nrf2, a transcription factor induced by oxidative stress, in INH induced apoptosis liver cancer cell lines.

Materials And Methods: Cytotoxicity was evaluated by MTT assay.

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Background: Previously, forced unilateral nostril breathing was associated with ipsilateral, or contralateral cerebral hemisphere changes, or no change. Hence it was inconclusive. The present study was conducted on 13 normal healthy participants to determine the effects of alternate nostril yoga breathing on (a) cerebral hemisphere asymmetry, and (b) changes in the standard EEG bands.

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Protein arginine methyltransferase-5 (PRMT5) plays an important role in cancer progression by repressing the expression of key tumor suppressor genes via the methylation of transcriptional factors and chromatin-associated proteins. However, very little is known about the expression and biological role of PRMT5 in head and neck cancer. In this study, we examined expression profile of PRMT5 at subcellular levels in oropharyngeal squamous cell carcinoma (OPSCC) and assessed its correlation with disease progression and patient outcome.

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Recent studies have shown that IL-6 signaling plays an important role in the aggressive and metastatic phenotype of head and neck squamous cell carcinoma (HNSCC). Therefore, we hypothesized that targeting of IL-6 signaling in HNSCC could enhance the therapeutic efficacy of standard chemoradiation treatment. We used both and models to test the efficacy of Bazedoxifene (BZA), a drug that was originally developed as a newer-generation selective estrogen receptor modulator (SERM) for the treatment of postmenopausal osteoporosis.

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