Design, synthesis and evaluation of aminothiazole derivatives as potential anti-Alzheimer's candidates.

The objective of the present study was to design, synthesize and evaluate diverse Schiff bases and thiazolidin-4-one derivatives of aminothiazole as key pharmacophores possessing acetylcholinesterase inhibitory activity. Two series of compounds (13 each) were synthesized and evaluated for their acetylcholinesterase inhibition and antioxidant activity. Molecular docking of all compounds was performed to provide an insight into their binding interactions.

Insights on Quercetin Therapeutic Potential for Neurodegenerative Diseases and its Nano-technological Perspectives.

The neurodegeneration process begins in conjunction with the aging of the neurons. It manifests in different parts of the brain as Aβ plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and other structures, which leads to progressive loss or death of neurons. Quercetin (QC) is a flavonoid compound found in fruits, tea, and other edible plants have antioxidant effects that have been studied from subcellular compartments to tissue levels in the brain.

Correction: COVID-19 and transportation of India: influence on infection risk and greenhouse gas emissions.

[This corrects the article DOI: 10.1007/s10668-022-02311-9.].

COVID-19 and transportation of India: influence on infection risk and greenhouse gas emissions.

COVID-19 have significant impact on travel behaviour and greenhouse gases (GHG), especially for the most affected city in India, Mumbai metropolitan region (MMR). The present study attempts to explore the risk on different modes of transportation and GHG emissions (based on change in travel behavior) during peak/non-peak hours in a day by an online/offline survey for commuters in Indian metropolitan cities like MMR, Delhi and Bengaluru. In MMR, the probability of infection in car estimated to be 0.