Publications by authors named "Arthur T Crossman"
Article Synopsis
- The study expands the use of copper(II) tetrafluoroborate as a catalyst to open epoxides with various types of alcohols.
- It explores different solvents to enhance the reaction process during the catalytic opening.
- Additionally, the research includes a method for purifying the resulting products from these reactions.
Article Synopsis
- * The N-acetylglucosamine-phosphatidylinositol de-N-acetylase (deNAc) is a key zinc metalloenzyme in this process, and several deoxy-2-C-branched monosaccharides with various substituents have been synthesized for testing.
- * The study finds that monosaccharides with carboxylic acid or hydroxamic acid groups effectively inhibit deNAc, with IC(50) values ranging from 0.1-1.5mM, while a
Article Synopsis
- A library of small zinc-binding groups (ZBGs) was created using deoxy-2-C-branched-monosaccharides, focusing on compounds like 1,5-anhydroglucitols, to study their interaction with a specific metalloenzyme involved in glycosylphosphatidylinositol biosynthesis.
- The library includes monodentate carboxylic acids and bidentate hydroxamic acids to evaluate how well they bind zinc, which is crucial for the enzyme's function.
- An additional compound, N-ureido thioglucoside, was synthesized and included because a similar compound previously displayed inhibitory effects on the enzyme, suggesting that the N-ureido structure plays a
1-D-6-O-[2-(N-hydroxyaminocarbonyl)amino-2-deoxy-alpha-D-glucopyranosyl]-myo-inositol 1-(n-octadecyl phosphate) was prepared to probe the reaction mechanism of the putative zinc-dependent metalloenzyme 2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1-->6)-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis.
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