Publications by authors named "Arthur Ledesma"
Article Synopsis
- - Solid tumors are increasingly common in various age groups and are often linked to high levels of cMET expression, complicating treatment due to the tumor's complexity and interconnected pathways.
- - The study introduces cMET-targeting Fab drug conjugates (FDCs), which combine a Fab fragment with a cytotoxic drug, investigated through both in vitro and in vivo testing.
- - FDCs show significant anti-tumor effectiveness against cMET-overexpressing cancer cells and human gastric tumors in mouse models, suggesting a promising new approach for treating solid tumors.
Coronavirus disease 2019 (COVID-19) continues to significantly impact the global population, thus countermeasure platforms that enable rapid development of therapeutics against variants of SARS-CoV-2 are essential. We report use of a phage display human antibody library approach to rapidly identify neutralizing antibodies (nAbs) against SARS-CoV-2. We demonstrate the binding and neutralization capability of two nAbs, STI-2020 and STI-5041, against the SARS-CoV-2 WA-1 strain as well as the Alpha and Beta variants.
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