Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells.

Background: Native bone marrow (BM) mesenchymal stem/stromal cells (BM-MSCs) participate in generating and shaping the skeleton and BM throughout the lifespan. Moreover, BM-MSCs regulate hematopoiesis by contributing to the hematopoietic stem cell niche in providing critical cytokines, chemokines and extracellular matrix components. However, BM-MSCs contain a heterogeneous cell population that remains ill-defined.

Simple foot an ankle value: a simple evaluation correlated to the existing PROMs.

Purpose: The SFAV (Simple Foot and Ankle Value) consists in asking patients how they rate their joint function on the day of the examination, as a percentage of that of a normal joint (0-100% scale with 100% being normal). The main objective was to validate the SFAV by determining its correlation with validated foot and ankle function scores.

Methods: This was a prospective study.

Pediatric Simple Knee Value: a simple patient-reported outcome measure for the knee.

Purpose: The pediatric Simple Knee Value (pedi-SKV) is an outcome score in which paediatric patients are asked 'How would you rate your knee today as a percentage of normal (0% to 100% scale with 100% being normal)?'. The primary aim of this study was to validate the pedi-SKV by measuring its correlation with validated knee function scores used most often in paediatric orthopaedics.

Methods: This prospective study was conducted at a teaching hospital to evaluate the pedi-SKV's validity.

A retrospective comparison of central and posterior hinge joints in 53 total knee arthroplasties.

Introduction: The number of hinged total knee arthroplasty (HTKA) procedures is constantly increasing. There are two hinge types: central (CHTKA) and posterior (PHTKA). The primary purpose of the study was to compare implant survival in patients with CHTKA versus PHTKA.

Does augmented core decompression decrease the rate of collapse and improve survival of femoral head avascular necrosis? Case-control study comparing 184 augmented core decompressions to 79 standard core decompressions with a minimum 2 years' follow-up.

Introduction: Avascular necrosis of the femoral head often progresses to femoral head collapse if not treated. Conservative treatment yields highly variable results and is not standardised, mainly because it is typically evaluated in small patient populations. This led us to conduct a large retrospective comparative study with the goals of 1) analysing survival and functional outcomes, 2) looking for differences in survival between core decompression techniques (standard versus augmented), and 3) studying the risk factors for femoral head collapse and revision by arthroplasty.

Simple Knee Value: a simple evaluation correlated to existing knee PROMs.

Purpose: The Simple Knee Value (SKV) is an outcome score in which patients are asked to grade their knee function as a percentage of that of a normal knee. The primary aim of this study was to validate the SKV by measuring its correlation with existing knee-related PROMs.

Methods: This was a prospective study conducted at a teaching hospital to assess the SKV's validity.