Publications by authors named "Arthur G Affleck"
The treatment of locally advanced rectal cancer has traditionally included sequenced multimodal therapy including radiation, chemotherapy, and surgery. The relative contribution of each and the order of treatments have evolved over the years. By the early twenty-first century, there was widespread use of the German Rectal Cancer Trial approach: preoperative chemoradiation, followed by standardized surgery including total mesorectal excision, and finally adjuvant chemotherapy.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates differences in gene expression between early-onset and late-onset colorectal cancer, focusing on immune genes like complement factor D.
- Researchers analyzed tumor samples from 121 patients using advanced techniques to validate these gene expressions and tested drugs that target these genes in mouse models.
- Findings showed that genes like complement factor D and BCL2 are more active in early-onset cases, and using drugs like danicopan and venetoclax in mice significantly reduced tumor size and weight.