Publications by authors named "Arthur A Reyes"
Article Synopsis
- Leptomeningeal inflammation in multiple sclerosis (MS) is linked to worse outcomes and increased cortical damage, but early therapies targeting this inflammation have not been effective.
- Researchers developed a model using ultra-high field MRI and SJL/J mice with experimental autoimmune encephalomyelitis to study meningeal inflammation over time, revealing significant immune cell infiltration.
- Inflammation persisted through weeks, allowing for testing of evobrutinib, a BTK inhibitor, in a randomized trial on the impact of this treatment on established meningeal inflammation.
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including in the CNS and the immune system. Whether bile acid metabolism is abnormal in MS is unknown.
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