Childhood-onset systemic lupus erythematosus associated with inborn errors of immunity: One or several conditions?

Childhood-onset systemic lupus erythematosus (cSLE) is a multisystem disease; its severity depends on the organs involved. Monogenic diseases have been described as predisposing to the onset of cSLE. Analytical and immunological tests are used for diagnostic confirmation.

Pylephlebitis in pediatrics: A diagnostic challenge.

Pylephlebitis is defined as suppurative thrombosis of the portal vein as a complication of abdominal infections. In pediatrics, the most frequent etiology is appendicitis, generally of late diagnosis, presenting as sepsis, with a high mortality rate. Imaging methods are necessary for diagnosis; the most common are the Doppler ultrasound and computed tomography angiography.

Brodie abscess in the clavicle: an uncommon presentation.

Osteomyelitis is defined as an inflammation of the bone caused by infection. Acute osteomyelitis is common in pediatrics. A Brodie abscess is a type of subacute osteomyelitis, with a historically low incidence; however, its incidence is currently increasing.

[The APO A/APO B ratio in the screening of patients at cardiovascular risk].

A brief introduction on the pathogenesis of atherosclerosis is followed by a review of the various tests used in screening subjects at cardiovascular risk including the new test to determine Apo A/Apo B measurement. The reliability of the various biohumoral indices in several sample groups is analysed and compared. It is concluded that variations in the Apo A/Apo B ratio are the most reliable indicator of patients at risk of heart disease.

[Vasodilator drugs in the therapy of chronic congestive heart failure. Clinico-case contribution].

After a review of the pathogenesis of congestive decompensation in the light of recent discoveries, the basis for the use of vasodilator drugs in such pathologies is discussed. The results of personal clinical experiments using hydralazine and isosorbide dinitrate are described with the conclusion that these drugs are really effective.