Identification of electromyographic patterns of bradykinesia in patients with Parkinson's disease.

Background: Parkinson's disease (PD) is a common neurodegenerative disease characterized by rest tremor, rigidity, and bradykinesia. Assessing the severity of these symptoms is typically done using the third part of the Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS III), relying on subjective evaluations by neurologists, which may lead to challenges in result interpretation. To address this issue, incorporation of surface electromyography (sEMG) in diagnostics.

Monitoring of Organochlorine Pesticides (OCP) in Hair Samples of Wild Herbivorous Mammals Living in Remote and Protected Areas of the Far East and Siberia of Russia.

Monitoring wildlife exposure to biological hazards is a critical component of the wildlife risk assessment. In this study 38 hair samples were collected from 8 different species from ten districts of Russian Far East and Siberia and analysed for the presence of organochlorine pesticides (OCP). 50% of the samples were contaminated with - p, p'-DDT, α-HCH and DDD.

Cascade Synthesis of Pyrrolo[1,2-]quinolines and Pyrrolo[2,1-]isoquinolines via Formal [3 + 2]-Cycloaddition of Push-Pull Nitro Heterocycles with Carbonyl-Stabilized Quinolinium/Isoquinolinium Ylides.

Various substituted pyrrolo[1,2-]quinolines and pyrrolo[2,1-]isoquinolines were synthesized in good to high yields by the EtN-mediated reaction of push-pull 3-nitrobenzofurans or 1-Ts-/1-Ms-3-nitroindoles and precursors of carbonyl-stabilized quinolinium and isoquinolinium ylides as 1,3-dipole equivalents. These transformations proceed in a one-pot manner starting with the formal [3 + 2]-cycloaddition stage, which is accompanied by double dearomatization of both quinoline/isoquinoline and benzofuran/indole moieties, followed by ring-opening of cyclic intermediate formed and nitrous acid elimination sequence. [3 + 2]-Cycloadducts were isolated as the final products in cases of impossibility or difficulty of their enolization.

Plasma Treatment Modifies Element Distribution in Seed Coating and Affects Further Germination and Plant Growth through Interaction with Soil Microbiome.

This study investigates the impact of plasma-seed interaction on germination and early plant development, focusing on and . The investigation delves into changes in chemical composition, water absorption, and surface morphology induced by plasma filaments generated in synthetic air. These analyses were conducted using scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS).

[Botulinum toxin type A (Relatox) in transition from medication overuse to non-overuse status in patients with chronic migraine: a subgroup analysis of phase IIIb randomized single-blind multicenter active-controlled parallel-group trial].

Objective: To access the effect of Relatox, the first Russian botulinum toxin type A, in patients with chronic migraine (CM) and medication overuse (MO).

Material And Methods: In phase IIIb single-blind randomized multicenter active-controlled parallel-group study, patients with CM were randomized to once intramuscular injections of Relatox (101) or onabotulinumtoxin A injections - Botox (108). This subgroup analysis evaluated the percentage of patients who transition from medication overuse to non overuse status from baseline; mean changes in the number of headache days, migraine headache days, acute headache medication intakes days, headache intensity, proportion of patients who had a ≥50% reduction in headache days, proportion of the patients with severe (≥60) Headache Impact Test-6 score and with a severe (≥21) MIDAS score in a 28-day periods in each treatment among patients with baseline acute medication overuse via repeated measures.

[Botulinum toxin type A (Relatox) in the treatment of chronic migraine in adults: results of phase IIIb, randomized, one-blind, multicenter, active-controlled, parallel-group trial].

Objective: To access the efficacy and safety of the first Russian botulinum toxin type A (Relatox) as a headache prophylaxis in adult with chronic migraine (CM).

Material And Methods: The randomized, one-blind, multicenter, active-controlled, parallel-group trial study involved 209 patients with CM aged from 19 to 65 years. The patients were randomized to injections of the Russian botulinum toxin type A - Relatox (=101) or onabotulinumtoxinA injections - Botox (=108).

Oxyethylated Fluoresceine-(thia)calix[4]arene Conjugates: Synthesis and Visible-Light Photoredox Catalysis in Water-Organic Media.

Fluorescent derivatives attract the attention of researchers for their use as sensors, photocatalysts and for the creation of functional materials. In order to create amphiphilic fluorescent derivatives of calixarenes, a fluorescein derivative containing oligoethylene glycol and propargyl groups was obtained. The resulting fluorescein derivative was introduced into three different (thia)calix[4]arene azide derivatives.

Influence of Dy and Ho on the Phase Composition of the Ti-Al System Obtained by 'Hydride Technology'.

The manuscript describes the phase composition, microstructure, some physical and mechanical properties of the Ti-Al system with addition of 2 at. % Dy (TAD) and Ho (TAH) obtained by "hydride technology". Phase diagrams for Ti-Al-Dy and Ti-Al-Ho at a temperature of 1150 °C and basic properties for ternary phases Dy₆Ti₄Al₄₃ and Ho₆Ti₄Al₄₃ were calculated.

New Calix[4]arene-Fluoresceine Conjugate by Click Approach-Synthesis and Preparation of Photocatalytically Active Solid Lipid Nanoparticles.

New fluorescent systems for photocatalysis, sensors, labeling, etc., are in great demand. Amphiphilic ones are of special interest since they can form functional colloidal systems that can be used in aqueous solutions.

Migraine and light: A narrative review.

Objective: In this narrative review, we summarize clinical and experimental data on the effect of light in migraine and discuss future prospects.

Background: Effective nonpharmacological treatment of hypersensitivity to light in migraine is an unmet clinical need. Current management strategies primarily consist of seeking a dark room and avoiding light exposure.

Nursing, psychotherapy and advanced cancer: A scoping review.

Purpose: Many individuals with advanced cancer have unmet psychological needs and often lack access to supportive care. Psychotherapy for adults with advanced cancer is a promising way to address some of the challenges in meeting these care needs. Nurses are the largest cohort of healthcare workers who can practice as psychotherapists and are positioned ideally to integrate these interventions as part of routine care.

Catalyst-free formal [3 + 2] cycloaddition of stabilized ,-cyclic azomethine imines to 3-nitrobenzofurans and 3-nitro-4-chromenes: access to heteroannulated pyrazolo[1,2-]pyrazoles.

We have studied the [3 + 2]-cycloaddition of various ,-cyclic azomethine imines to 3-nitrobenzofurans. This process is a rare example of their dearomatization. We have also extended this process to the related 3-nitro-4-chromenes as dipolarophiles.

Simplex representation of molecular structure as universal QSAR/QSPR tool.

We review the development and application of the Simplex approach for the solution of various QSAR/QSPR problems. The general concept of the simplex method and its varieties are described. The advantages of utilizing this methodology, especially for the interpretation of QSAR/QSPR models, are presented in comparison to other fragmentary methods of molecular structure representation.

Human osteoblast-like SAOS-2 cells on submicron-scale fibers coated with nanocrystalline diamond films.

A unique composite nanodiamond-based porous material with a hierarchically-organized submicron-nano-structure was constructed for potential bone tissue engineering. This material consisted of submicron fibers prepared by electrospinning of silicon oxide (SiO), which were oxygen-terminated (O-SiO) and were hermetically coated with nanocrystalline diamond (NCD) films. The NCD films were then terminated with hydrogen (H-NCD) or oxygen (O-NCD).

Sleep Disorders and Headache: A Review of Correlation and Mutual Influence.

The review is devoted to the complex relationship between headache and sleep disorders. The shared neuroanatomical structures of the nervous system involved in pain perception and sleep are shown, and mechanisms of comorbidity between headaches and sleep disorders are considered. Various types of headaches in the continuum of the sleep-wake cycle are described.

Ecological and Geochemical Conditions for the Accumulation of Antioxidants in the Leaves of (L.) Bigel.

The article explores how location affected the dynamics of accumulation of ascorbic acid (AC) and oxidized forms of AC-dehydroascorbic acid (DAA) and diketogulonic acid (DKGA) in beach pea during ontogenetic development. Our analysis focuses on research of the ecological and geochemical conditions growing of the plant on the Curonian Spit. The level of hydrogen peroxide and the activity of enzymes that break it down were analyzed.

Behavioral impacts of a mixture of six pesticides on rats.

Pesticides can potentially contribute to the development of numerous neurodegenerative diseases. This study evaluates the effects of a six-pesticide mixture at doses around the no-observed-adverse-effectlevels (0 × NOAEL, control) and 0.25, 1 and 5 × NOAEL on behavior of Wistar rats.

[Migraine burden and clinical inertia: what can we do?].

Aim: To study the compliance of neurologists and headache specialists to chronic headache and chronic migraine (CM) diagnosis and treatment guidelines.

Material And Methods: The survey included 634 neurologists from all regions of the Russian Federation. Mean age of respondents was 40.

[Experience of using the chondroprotector Sustagard Artro (sashe) in the treatment of lower back pain].

Aim: To compare the efficacy of oral administration of the chondroprotector (CP) Sustagard Artro and nonsteroidal anti-inflammatory drugs (NSAIDs) in reducing lower back pain and to assess the level of blood glucose in patients taking CP.

Material And Methods: Sixty patients with spondylarthrosis (SA) were studied. Patients were randomized into the CP group (n=30), which received Sustagard Artro (1 sachet once a day for 6 weeks), and the NSAIDs group (n=30) treated with injectable forms of different groups of NSAIDs for 3-7 days.

Infrared Absorption Spectroscopy of Albumin Binding with Amine-Containing Plasma Polymer Coatings on Nanoporous Diamond Surfaces.

Nanocrystalline diamond (NCD) layers functionalized with amine-containing functional groups have generated considerable interest as biocompatible substrates for attachment of biomolecules and cells with a view to biosensor and tissue engineering applications. Here we prepare nanoporous diamond layers with the surfaces modified by hydrogen plasma, oxygen plasma, and conformal 7 nm amine-containing plasma polymer (PP). Immobilization of bovine serum albumin (BSA) molecules is characterized on such surfaces.

Far Away from Flatland. Synthesis and Molecular Structure of Dihetera[3.3.]propellanes and Trihetera[3.3.]propellanes: Advanced Analogues of Morpholine/Piperazine.

An approach to di- and trihetera[3.3.]propellanes ( = 2-4 ), advanced morpholine and piperazine analogues, is developed.

Scalable Synthesis of Biologically Relevant Spirocyclic Pyrrolidines.

Synthetic approaches toward multigram preparation of spirocyclic α,α-disubstituted pyrrolidines from readily available starting materials are discussed. It was shown that although a number of synthetic methodologies have been known to date, many of the title compounds remain hardly accessible. The most appropriate literature method (which relied on reaction of imines and allyl magnesium halide, followed by bromocyclization) was identified and optimized.

[Real-world migraine burden: clinical and economic aspects].

Aim: To evaluate the rationale for different approaches to preventive chronic migraine (CM) treatment by comparing clinical outcomes and financial burden of the disease in the real-world practice.

Material And Methods: Sixty-six patients with CM were enrolled at the Alexander Vein Headache Clinic (60 women and 6 men, aged 28-51). All patients were divided into 3 groups: group 1 (n=22) received oral preventative treatment with topiramate, up to 100 mg daily, for three months; group 2 (n=20) received 12 acupuncture sessions (3 sessions a week); group 3 (n=24) received 155-195 units of botulinum toxin type A (botox, BTA).

Silicon-Vacancy Centers in Ultra-Thin Nanocrystalline Diamond Films.

Color centers in diamond have shown excellent potential for applications in quantum information processing, photonics, and biology. Here we report the optoelectronic investigation of shallow silicon vacancy (SiV) color centers in ultra-thin (7⁻40 nm) nanocrystalline diamond (NCD) films with variable surface chemistry. We show that hydrogenated ultra-thin NCD films exhibit no or lowered SiV photoluminescence (PL) and relatively high negative surface photovoltage (SPV) which is ascribed to non-radiative electron transitions from SiV to surface-related traps.

Hydroxylation and self-assembly of colloidal hydrogenated nanodiamonds by aqueous oxygen radicals from atmospheric pressure plasma jet.

Plasma chemical surface modification of nanoparticles in gas-liquid type reactors enables a controllable, specific, low-cost, and environmentally friendly alternative to wet chemistry methods or thermal and dry plasma treatments. Here the atmospheric pressure radio-frequency microplasma jet (µ-APPJ) operating with 0.6% O in He is used to deliver aqueous oxygen radicals (AOR) to the surface of ∼3 nm hydrogenated detonation nanodiamonds (H-DNDs) suspended in water.