Publications by authors named "Artem Ten"

Article Synopsis
  • Membrane-associated 70 kDa heat shock protein (mHsp70) plays a crucial role in the migration and invasion of malignant brain tumor cells, as observed in patient samples.
  • Advanced techniques like inverted confocal microscopy and mass spectrometry showed that mHsp70 is prominently expressed on the surface of cancer cells, particularly in areas surrounding the tumors.
  • Inhibiting HSP70 with small molecules significantly reduced cancer cell invasiveness and delayed tumor progression in animal models, suggesting that targeting mHsp70 could be a promising strategy for developing new cancer therapies.
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The tumor microenvironment (TME) plays an important role in the process of tumorigenesis, regulating the growth, metabolism, proliferation, and invasion of cancer cells, as well as contributing to tumor resistance to the conventional chemoradiotherapies. Several types of cells with relatively stable phenotypes have been identified within the TME, including cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), neutrophils, and natural killer (NK) cells, which have been shown to modulate cancer cell proliferation, metastasis, and interaction with the immune system, thus promoting tumor heterogeneity. Growing evidence suggests that tumor-cell-derived extracellular vesicles (EVs), via the transfer of various molecules (e.

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Over the past several decades, nanocarriers have demonstrated diagnostic and therapeutic (i.e., theranostic) potencies in translational oncology, and some agents have been further translated into clinical trials.

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