Publications by authors named "Artem Ilyasov"
Magnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely analyzed. Here, we first perform comparative temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models - breast (4T1) and colon (CT26) cancer in vitro and in vivo.
View Article and Find Full Text PDFRecently neutrophil-based nanoparticles (NPs) drug delivery systems have gained considerable attention in cancer therapy. Numerous studies have been conducted to identify optimal NPs parameters for passive tumor targeting, while there is a fundamental dearth of knowledge about the factors governing cell-mediated delivery. Here, by using intravital microscopy and magnetic resonance imaging, we describe accumulation dynamics of 140 nm magnetic cubes and clusters in murine breast cancer (4T1) and colon cancer (CT26) models.
View Article and Find Full Text PDFArticle Synopsis
- Developing effective nanocarriers for targeted organ delivery and safe elimination is complex, particularly due to factors like size and composition influencing biodistribution.
- Recent studies indicate that nanoparticles larger than the traditional renal clearance threshold can still be expelled through urine, challenging previous beliefs about the limits of nanoparticle size in excretion.
- Research using advanced imaging techniques showed that PEGylated iron oxide nanoparticles accumulate quickly in the kidneys and can be excreted intact, suggesting a new pathway for renal clearance beyond the conventional glomerular filtration limits.