Synthesis, biological evaluation and molecular docking of methoxy n-phenylpyrazoline derivatives as anticancer agents.

This research aims to synthesize some N-phenylpyrazoline derivatives with methoxy substituents and study their activity as potent anticancer agents as well as their interaction with the EGFR receptor on cancer cells. The synthesis of N-phenylpyrazolines was carried out via cyclocondensation reaction of chalcones and phenylhydrazine. All products were elucidated using GC-MS, FT-IR, H- and C-NMR spectrometers.

A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells.

Objective: Metastasis causes approximately 90% of cancer-related deaths, including in cervical cancer patients. Uncontrolled cell proliferation, migration, and cancer stemness act as critical events in primary tumor growth and cancer metastasis progression in cervical cancer. Here, we investigated the anti-proliferative, anti-migration, and cancer stemness inhibition activity of N-phenyl pyrazoline derivatives against cervical cancer cells.