Publications by authors named "Arslan Hussain LodhI"
Article Synopsis
- The study investigates how sodium hydrosulfide (NaHS) and L-arginine may protect against nephrotoxicity caused by cisplatin, a common chemotherapy drug, in rats.
- Rats were treated with cisplatin and then given either NaHS, L-arginine, or both for 28 days, with various biological samples collected for analysis.
- Results showed that both treatments improved kidney function and reduced oxidative stress markers, with the combination of NaHS and L-arginine providing the best protective effects against cisplatin toxicity.
Aim: Depression is a chronic recurrent neuropsychiatric disorder associated with inflammation. This study explored the pharmacological activities of leaves crude extract (Aj.Cr) on lipopolysaccharide (LPS)-induced depressive-like behavior in experimental mice.
View Article and Find Full Text PDFPlants of the genus have notable use in folklore medicines as well as being used for pharmacological purposes. The present work explored the biological predispositions of and attempted to accomplish a comprehensive chemical profile through GC-MS of different fractions concerning polarity (chloroform and -butanol) and LC-ESI-MS of methanolic extract by both positive and negative ionization modes. The biological characteristics such as antioxidant potential were assessed by applying six different methods.
View Article and Find Full Text PDFAim: Liver regulates metabolism of biomolecules and injury of liver causes distortion of metabolic functions. This injury may be oxidative or inflammatory induced by numerous factors including alcohol, pathogens and xenobiotics. This scientific study was planned to investigate the anti-inflammatory and anti-oxidant potential of p-coumaric acid (p-CA) on Lipopolysaccharide/D-Galactosamine (LPS/D-GalN) induced liver injury.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the phytochemical composition and biological activities of L. extracts with different polarities, using techniques like HPLC and GC-MS to identify and quantify various phytochemicals.
- The extracts demonstrated significant antioxidant properties, with the methanol extract showing the highest radical-scavenging activity, while the hexane fraction exhibited strong enzyme-inhibiting effects against xanthine oxidase and urease.
- Additionally, all extracts displayed moderate antibacterial activity against seven bacterial strains, and molecular docking suggested specific interactions between certain phytochemicals and the target enzyme, xanthine oxidase.
Purpose: Persistent hyperglycemia lead towards depletion of hydrogen sulfide (HS) resulting in generation of oxidative stress and diabetic nephropathy. The aim of the current study was to explore the antioxidant potential of HS and captopril, a -SH containing compound in streptozotocin (STZ)-induced diabetic nephropathy.
Methods: Fifty four Wistar-Kyoto (WKY) rats male (200-250g) were divided into nine groups (n=6) with each group injected once with STZ (60mg/kg i.