Publications by authors named "Arshi Beg"

Article Synopsis
  • Pure intertubular seminoma (PITS) is a rare type of testicular cancer where seminoma cells are found in testicular interstitium without forming a noticeable mass or diffuse growth, leading to challenges in diagnosis.
  • This condition often goes unnoticed and is usually diagnosed incidentally during evaluations for testicular pain, infertility, or other issues, with only a minority of cases presenting with metastasis.
  • A study involving 15 patients revealed that the average age at presentation was 29, and common symptoms included undescended testis, testicular pain, and infertility, while most patients had normal serum markers and no visible tumors at the time of diagnosis.
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Spindle cell/sclerosing rhabdomyosarcoma is a rare neoplasm and has an aggressive clinical course. Because of its rarity, we performed a multi-institutional collaboration to comprehend the overarching clinical, histopathological, and immunohistochemical characteristics of a cohort of spindle cell/sclerosing rhabdomyosarcoma. Forty-five patients with spindle cell/sclerosing rhabdomyosarcoma were identified.

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Background: Urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC) harbor analogous morphology with comparable cytogenetic changes as well as prognostic factors but their similar biological activities still remain controversial. SLITRK6 gene has been demonstrated to have distinct role in urothelial cancers with a distinction between UTUC and UBUC.

Method: The study included a total of 80 patients of urothelial carcinoma including 60 UBUC and 20 UTUC cases.

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Article Synopsis
  • - The diagnosis of neuroblastoma can be difficult due to similarities with other pediatric tumors, so this study evaluates the effectiveness of GATA3 and ISL1 as distinguishing markers for neuroblastoma.
  • - In a study of 74 tumors, GATA3 was found to be highly sensitive and specific for neuroblastoma, with 100% sensitivity and 90% accuracy, while ISL1 also showed notable sensitivity and specificity but was less effective than GATA3.
  • - GATA3 and ISL1 could help differentiate neuroblastoma from other similar tumors in pediatric cases, potentially improving diagnostic accuracy and treatment decisions.
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Background: Primary mediastinal germ tumours (PMGCT) constitute, a mere 3-4% of all germ cell tumours (GCT). Although they account for approximately 16% of mediastinal tumours in adults and 19-25% in children as per western literature, there is hardly any large series on PMGCT reported from the Indian subcontinent.

Design: We have retrospectively analysed clinicopathological features of 98 cases of PMGCT diagnosed over 10 years (2010-2019) from a tertiary-care oncology centre.

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