Publications by authors named "Arshad Raodah"
FEMS Yeast Res
December 2009
Article Synopsis
- Wiskott-Aldrich syndrome (WAS) is linked to mutations in the WASP protein, especially within its WH1 domain, which is crucial for binding to the WASP-interacting protein (WIP).
- Research using a yeast strain lacking Las17p (a yeast version of WASP) revealed that 13 out of 52 analyzed missense mutations in WASP couldn't restore growth, indicating they may directly contribute to WAS in humans.
- Most problematic mutations were found in the WH1 domain, suggesting they disrupt the interaction between WASP and WIP, while mutations outside this domain don't affect the binding but may still alter the function of the complex.
