Bioactive profiling of L. from the Hail region of Saudi Arabia: a study on its phytochemical and elemental analysis, antibiofilm, antibacterial, antioxidant properties, and molecular docking analysis.

Background: is a wild leafy plant belonging to the family Polygonaceae, renowned for its therapeutic benefits. The genus Rumex comprises approximately 150 species distributed globally.

Objective: The study aimed to investigate the biological activities of using in vitro and methods.

ANN-based swarm intelligence for predicting expansive soil swell pressure and compression strength.

This research suggests a robust integration of artificial neural networks (ANN) for predicting swell pressure and the unconfined compression strength of expansive soils (PUCS-ES). Four novel ANN-based models, namely ANN-PSO (i.e.

Analyzing injury severity of three-wheeler motorized rickshaws: A correlated random parameters approach with heterogeneity in means.

Traffic crashes involving three-wheeler motorized rickshaw (3-WMR) are alarming public health and socioeconomic concerns in developing countries. While most of the earlier studies have dealt with safety analysis of four- and two-wheelers, there is a noticeable gap in understanding the safety dynamics, especially the risk factors affecting the crashes involving 3-WMR. The present study aims to address this gap by exploring potential risk factors influencing 3-WMR crashes, utilizing a correlated random parameters multinomial logit model with heterogeneity in means (CRPMNLMHM).

Effect of Mirabegron in Men With Overactive Bladder and Erectile Dysfunction: A Prospective Observational Study.

Background: As it has been observed that the erect penis has been the epitome of virility for the male community for decades, it became necessary to search for alternative treatments for the cause. So, the study was performed to evaluate the potential impact of mirabegron in men with mild to moderate erectile dysfunction (ED) and overactive bladder (OAB).

Methods: It was a prospective, observational study that was carried out at the Department of Urology at Rajendra Institute of Medical Sciences, Ranchi, for a duration of two years and included a total of two hundred fifty patients.

Optimization of laccase from Stenotrophomonas maltophilia E1 by submerge fermentation using coconut husk with its detoxification and biodecolorization ability of synthetic dyes.

Enzymatic degradation of synthetic dyes holds an immense promise for addressing the environmental concerns associated with the textile and dye industries. This study aimed to isolate bacteria capable of producing laccase enzymes from an anthropogenic environment. Subsequently, viability of utilizing cost-effective agricultural residues as substrates for laccase production was assessed.

Identification of TBK1 inhibitors against breast cancer using a computational approach supported by machine learning.

The cytosolic Ser/Thr kinase TBK1 is of utmost importance in facilitating signals that facilitate tumor migration and growth. TBK1-related signaling plays important role in tumor progression, and there is need to work on new methods and workflows to identify new molecules for potential treatments for TBK1-affecting oncologies such as breast cancer. Here, we propose the machine learning assisted computational drug discovery approach to identify TBK1 inhibitors.

Induced pluripotent stem cells (iPSCs): Where are we and where are we heading?

Induced Pluripotent Stem Cells (iPSCs) offer a unique therapeutic tool. The extent of the ongoing clinical studies substantiates the role of these cells in a highly promising area of personalized medicine. The employment of this technology in translational research is on the horizon.

Spices as Sustainable Food Preservatives: A Comprehensive Review of Their Antimicrobial Potential.

Throughout history, spices have been employed for their pharmaceutical attributes and as a culinary enhancement. The food industry widely employs artificial preservatives to retard the deterioration induced by microbial proliferation, enzymatic processes, and oxidative reactions. Nevertheless, the utilization of these synthetic preservatives in food products has given rise to significant apprehension among consumers, primarily stemming from the potential health risks that they pose.

DISPEL: database for ascertaining the best medicinal plants to cure human diseases.

Medicinal plants are anticipated to be one of the most valuable resources for the remedial usage in the treatment of various ailments. The data on key medicinal plants and their therapeutic efficacy against various ailments are quite scattered and not available on a single platform. Moreover, currently there is no means/mechanism of finding the best medicinal plant(s) from numerous plants known to cure any disease.

Circular Penile Skin Fasciocutaneous Ventral Onlay Flap Urethroplasty as an Alternative to Dorsal Onlay Buccal Mucosal Graft Urethroplasty in Complex Long-Segment Urethral Stricture: A Retrospective Study.

Background A urethral stricture is the narrowing of the urethra that results in symptoms of obstruction. It can appear anywhere along the male urethra's length and has a variety of causes. The circular penile fasciocutaneous flap is employed in the successful single-stage reconstruction of long-segment complex anterior urethral strictures especially when the buccal mucosa is unavailable due to various reasons.

A Study of Normal Renal Dimensions at Ultrasonography and Their Influencing Factors in an Indian Population.

Kidney dimensions play one of the most vital roles in the diagnosis and identification of any renal disease. Renal dimensions are generally used in clinical practices to determine the size of the kidney as well as correlate with renal function to have a better understanding of acute and chronic renal diseases. This study aimed to find out the normal renal dimensions with the help of ultrasonography and their impact on the Indian population.

Identification of Causative agents associated with decay of Trees Twig and Orchards Die-back and their Impacts on Vessels of Citrus, Date Palm and Ficus.

The present work is concerned with the studies of the organism causing wood decay of twigs and branches of citrus orchards, date palm Phoenix dactylifera L, and ficus trees. A survey for the occurrence of this disease in the main growing areas was achieved by the researchers. The following species of citrus orchards [lime (C.

Recent advances in applications of artificial intelligence in solid waste management: A review.

Efficient management of solid waste is essential to lessen its potential health and environmental impacts. However, the current solid waste management practices encounter several challenges. The development of effective waste management systems using advanced technologies is vital to overcome the challenges faced by the current approaches.

Prediction Models for Estimating Compressive Strength of Concrete Made of Manufactured Sand Using Gene Expression Programming Model.

The depletion of natural resources of river sand and its availability issues as a construction material compelled the researchers to use manufactured sand. This study investigates the compressive strength of concrete made of manufactured sand as a partial replacement of normal sand. The prediction model, i.

Temporal Instability of Factors Affecting Injury Severity in Helmet-Wearing and Non-Helmet-Wearing Motorcycle Crashes: A Random Parameter Approach with Heterogeneity in Means and Variances.

Not wearing a helmet, not properly strapping the helmet on, or wearing a substandard helmet increases the risk of fatalities and injuries in motorcycle crashes. This research examines the differences in motorcycle crash injury severity considering crashes involving the compliance with and defiance of helmet use by motorcycle riders and highlights the temporal variation in their impact. Three-year (2017-2019) motorcycle crash data were collected from RESCUE 1122, a provincial emergency response service for Rawalpindi, Pakistan.

Modelling Compression Strength of Waste PET and SCM Blended Cementitious Grout Using Hybrid of LSSVM Models.

Nowadays, concretes blended with pozzolanic additives such as fly ash (FA), silica fume (SF), slag, etc., are often used in construction practices. The utilization of pozzolanic additives and industrial by-products in concrete and grouting materials has an important role in reducing the Portland cement usage, the CO emissions, and disposal issues.

Attenuation of ovalbumin-induced inflammation and lung oxidative injury in asthmatic rats by extract: combined in silico and in vivo study on antioxidant potential, STAT6 and TNF- pathways.

In the present study we focused on the anti-asthmatic and antioxidant effects of L. (ZO) aqueous extract. This study includes 20 adult male rats, which were grouped into four; Group I: control group; Group II: asthmatic group (Ovalbumin sensitized/challenge model, Oval group); Group III: received ovalbumin sensitized/challenge associated a dose of 207 mg/kg body weight (BW) of ZO (Oval + D1 group); Group IV: received ovalbumin sensitized/challenge associated a dose of 414 mg/k BW of ZO (Oval + D2 group).

Predicting Bond Strength between FRP Rebars and Concrete by Deploying Gene Expression Programming Model.

Rebars made of fiber-reinforced plastic (FRP) might be the future reinforcing material, replacing mild steel rebars, which are prone to corrosion. The bond characteristics of FRP rebars differ from those of mild steel rebars due to their different stress-strain behavior than mild steel. As a result, determining the bond strength (BS) qualities of FRP rebars is critical.

GEP Tree-Based Prediction Model for Interfacial Bond Strength of Externally Bonded FRP Laminates on Grooves with Concrete Prism.

Reinforced concrete structures are subjected to frequent maintenance and repairs due to steel reinforcement corrosion. Fiber-reinforced polymer (FRP) laminates are widely used for retrofitting beams, columns, joints, and slabs. This study investigated the non-linear capability of artificial intelligence (AI)-based gene expression programming (GEP) modelling to develop a mathematical relationship for estimating the interfacial bond strength (IBS) of FRP laminates on a concrete prism with grooves.

-Derived Biosurfactant Attenuates Quorum Sensing-Mediated Virulence and Biofilm Formation in and .

Quorum sensing (QS) controls the expression of diverse biological traits in bacteria, including virulence factors. Any natural bioactive compound that disables the QS system is being considered as a potential strategy to prevent bacterial infection. Various biological activities of biosurfactants have been observed, including anti-QS effects.

Enhancement of Confinement in Scaled RC Columns using Steel Fibers Extracted from Scrap Tyres.

Steel fibers are widely extracted from scrap tyres, causing environmental concerns. This paper presents the use of steel fibers in variable proportions extracted from scrap tyres. The enhancement of the confinement was envisaged through the addition of steel fibers obtained from scrap tyres.

Kidney injury and oxidative damage alleviation by : pharmacokinetics and protective approach in a combined murine model of osteoporosis.

Ginger () is considered as a nutraceutical spice, which possesses several health promotion and benefits. This study was carried out to investigate the phyto-chemical composition, the antioxidant capacities, the drug-likeness, and pharmacokinetic properties of ginger extract on kidney injury-associated osteoporosis in rats. Phenolic and flavonoid contents were assessed by standard chemical analysis methods and HPLC.