Publications by authors named "Arseniy V Akopyan"
Article Synopsis
- Understanding the fitness landscape is crucial for grasping how genetic information results in functional organisms, with this study examining the His3 gene involved in histidine synthesis in various species.
- Only 15% of amino acids in yeast His3 orthologues were consistently neutral, while the other 85% had fitness effects that varied based on the genetic context.
- About 67% of amino acid substitutions exhibited sign epistasis, showing different fitness impacts depending on the genetic background, contributing to a complex fitness landscape where many optimal paths are blocked.
