Publications by authors named "Arsene Nyalundja"

Article Synopsis
  • Brain tumors pose a major global health issue, particularly in Africa, where limited access to diagnostics and treatment amplifies the crisis and lack of standardized cancer protocols.
  • The Brain Tumor Consortium for Africa (BTCA) was created in 2023 to enhance CNS tumor diagnosis and care in Sub-Saharan Africa, identifying gaps in neuro-oncology capacity through a survey.
  • The consortium aims to improve brain tumor management by expanding molecular diagnostics, standardizing biobanking, enhancing data collection, and advocating for better care in healthcare policies.
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Data from the global South show higher COVID-19-related mortality in children compared to the North. Parents' willingness to vaccinate their children once COVID-19 vaccines are available is poorly documented. We assessed parents' willingness to vaccinate their children in the DRC.

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Article Synopsis
  • Mining activities in South Kivu, Democratic Republic of Congo, may significantly contribute to an increased prevalence of visible birth defects (BDs) among newborns, with a recorded rate of 399 cases per 100,000 live births between 2016-2021.
  • A cross-sectional study involving 65,474 newborns found that those living in mining zones had more than double the risk of developing visible BDs compared to those in non-mining zones, with specific regions like Mwenga showing even higher risk.
  • Common types of birth defects included musculoskeletal and central nervous system issues, highlighting the need for further research to explore the relationship between mining activities and birth defects.
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Article Synopsis
  • Acute spinal cord infarction (SCI) is a rare condition that is challenging to diagnose due to variable clinical features and limitations in MRI detection, prompting researchers to evaluate patient characteristics and diagnostic methods.
  • A systematic review of studies found that early intervention, particularly spinal surgical decompression, is linked to better patient outcomes, with a significant percentage benefiting from surgery compared to medical treatments alone.
  • The study highlighted that the T2 diffusion-weighted imaging (DWI) technique has moderate accuracy in identifying hyperacute spinal cord injuries, specifically during the critical first 6 hours after onset.
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Introduction: Approximately 33 million people suffer catastrophic health expenditure (CHE) from surgery and/or anesthesia costs. The aim of this systematic review is to evaluate catastrophic and impoverishing expenditure associated with surgery and anesthesia in low- and middle-income countries (LMICs).

Methods: We performed a systematic review of all studies from 1990 to 2021 that reported CHE in LMICs for treatment of a condition requiring surgical intervention, including cesarean section, trauma care, and other surgery.

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COVID-19 vaccine hesitancy and its enablers shape community uptake of non-covid vaccines such as the oral cholera vaccine (OCV) in the post-COVID-19 era. This study assessed the impact of COVID-19 vaccine hesitancy and its drivers on OCV hesitancy in a cholera-endemic region of the Democratic Republic of Congo. We conducted a community-based survey in Bukavu.

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Two novel vaccines against malaria are proposed as a complementary control tool to prevent and reduce related disease and death in under-five children from moderate to high malaria transmission regions. The Democratic Republic of Congo (DRC) has committed to eradicate malaria by 2030, and significant efforts have been deployed to strengthen control and elimination measures. We aimed to understand factors influencing the malaria vaccine acceptability among the general population in eastern DRC.

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Objective: Brain tumors are a global problem, leading to higher cancer-related morbidity and mortality rates in children. Despite the progressive though slow advances in neuro-oncology care, research, and diagnostics in sub-Saharan Africa (SSA), the epidemiological landscape of pediatric brain tumors (PBTs) remains underestimated. This study aimed to systematically analyze the distribution of PBT types in SSA.

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Since 2018, a neurosurgery delegation has been actively engaged and consistently present at the World Health Assembly. Recognizing the growing impact of neurosurgical diseases, the neurosurgery delegation participated in the 76th World Health Assembly in May 2023, advocating for timely, safe, and affordable global neurosurgical care. The delegation focused on forging new collaborations, strengthening the World Health Organization-World Federation of Neurosurgical Societies official relations, and actively supporting resolutions that impact the neurosurgical patients.

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Meningiomas are the most frequent nonmalignant tumors of the central nervous system (CNS). Despite their benign nature and slow-growing pattern, if not diagnosed early, these tumors may reach relatively large sizes causing significant morbidity and mortality. Some variants are located in hard-to-access locations, compressing critical neurovascular structures, and making the surgical management even more challenging.

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Background: Expansive intracranial hematomas (EIH) following traumatic brain injury (TBI) continue to be a public health problem in Uganda. Data is limited regarding the neurosurgical outcomes of TBI patients. This study investigated the neurosurgical outcomes and associated risk factors of EIH among TBI patients at Mulago National Referral Hospital (MNRH).

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Purpose Of Review: This review aims at providing updates on selected post-stroke complications. We examined recent advances in diagnosing and treating the following post-stroke complications: cognitive impairment, epilepsy, depression, fatigue, tremors, dysphagia, and pain.

Recent Findings: Advances in understanding the mechanisms of post-stroke complications, in general, are needed despite advances made in understanding, treating, and preventing these complications.

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Background: In a resource-limited setting such as sub-Saharan African countries, neurosurgeons need training and fellowship for surgical repair of aneurysmal subarachnoid hemorrhage (aSAH). Surgical repair of ruptured aneurysms costs less and requires less instrumentation compared with endovascular procedures. The purpose of this study is to evaluate the state of training and management of aSAH in sub-Saharan Africa training centers.

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Background: The prediction of raised Intracranial Pressure (ICP) with accuracy in Traumatic Brain Injury (TBI) patients is a clinically important decision and therapeutic tool. This study aimed to evaluate the existing methods used for non-invasive ICP monitoring in TBI patients in LMICs.

Methods: Systematic searches of PubMed, Google Scholar, and ScienceDirect were performed from database inception to November 2021.

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Background: This study looks at how COVID-19 affected the admission and training of neurosurgical residents worldwide.

Methods: From 2019 to 2021, we reviewed multiple databases (i.e.

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Neurosurgical practice in the Democratic Republic of Congo (DRC) is challenged by limited resources and infrastructure. The DRC has 16 local residing neurosurgeons for 95 million inhabitants, a ratio of 1 neurosurgeon per 5.9 million Congolese citizens.

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Background: Sub-Saharan African (SSA) neuro-oncologists report high workloads and challenges in delivering evidence-based care; however, these reports contrast with modeled estimates of adult neuro-oncology disease burden in the region. This scoping review aimed to better understand the reasons for this discrepancy by mapping out the SSA adult brain tumor landscape based on published literature.

Methods: Systematic searches were conducted in OVID Medline, Global Index Medicus, African Journals Online, Google Scholar, and faculty of medicine libraries from database inception to May 31, 2021.

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Introduction: Low- and middle-income countries bear the majority of neurosurgical disease burden and patients face significant barriers to seeking, reaching, and receiving care. We aimed to understand barriers to seeking care among adult Africans by evaluating the public perception, knowledge of availability, and readiness to use neurosurgical care services.

Methods: An e-survey was distributed among African adults who are not in the health sector or pursuing a health-related degree.

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Background: A significant proportion of the public rely on the internet for their health information, and social media has emerged as the principal information source. YouTube is the world's largest and most popular video library, and it has emerged as a primary health information source because it offers animated and interactive content. However, little is known of its usefulness of neurosurgery videos to African YouTube users.

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Article Synopsis
  • Global surgery is becoming an important area of study in global health, but it suffers from authorship inequities, particularly over-representation of authors from high-income countries (HICs) and under-representation of those from low- and middle-income countries (LMICs).
  • A systematic analysis of global surgery publications from 2016 to 2020 revealed that the majority of authors were male (60%), primarily from HICs (51%), and held senior positions (55% were fully qualified clinicians or in leadership roles).
  • The study highlights significant gender and seniority disparities, especially with LMIC authors having fewer female authors and that more efforts are needed to improve authorship opportunities for underrepresented groups in global surgery research.
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Background: Barriers to care cause delays in seeking, reaching, and getting care. These delays affect low-and middle-income countries (LMICs), where 9 out of 10 LMIC inhabitants have no access to basic surgical care. Knowledge of healthcare utilization behavior within underserved communities is useful when developing and implementing health policies.

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Background: The global burden of neurosurgical disease is substantial, particularly in low- and middle-income countries (LMICs). Medical conferences are important in connecting those from LMICs to those from high-income countries for support and serve as an educational and networking tool. In this study, we sought to quantitatively assess the incorporation of global neurosurgery topics in international conferences related to the neurosurgical specialty.

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Background: Scientometrics is used to assess the impact of research in several health fields, including Anesthesia and Critical Care Medicine. The purpose of this study was to identify contributors to highly-cited African Anesthesia and Critical Care Medicine research.

Methods: The authors searched Web of Science from inception to May 4, 2020, for articles on and about Anesthesia and Critical Care Medicine in Africa with ≥2 citations.

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Introduction: Three million African patients need a neurosurgical consultation every year, but there are not enough neurosurgeons to meet this need. Efforts have been made to increase the neurosurgical capacity through the creation of training programs in Africa. Although these programs have been successful, there is still a long way to go.

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