Triple monoclonal protein-related kidney lesions in a patient with plasma cell dyscrasia: a case report.

A toxic monoclonal protein typically results in a single kidney pathology due to the specific biophysical characteristics of monoclonal proteins. Multiple monoclonal protein lesions are rarely reported and often portend a poor prognosis. We present a 57-year-old male who developed rapidly progressive glomerulonephritis after concealed ruptured diverticulitis.

Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation.

High-calorie diets increase the risk of developing obesity, cardiovascular disease, type-two diabetes (T2D), and other comorbidities. These "overnutrition" diets also promote the accumulation of a variety of harmful lipids in the heart and other peripheral organs, known as lipotoxicity. However, the mechanisms underlying lipotoxicity and its influence on pathophysiology remain unknown.

An Interesting Case of Congenital Intrahepatic Porto-hepatic Shunt as a Cause of Unexplained Encephalopathy.

Congenital portosystemic shunts can be divided into two types: intrahepatic shunts in which there is an abnormal connection between the branches of the portal vein and either the inferior vena cava or the hepatic veins and less commonly the extrahepatic type in which the portal system is connected to one of the branches of the mesenteric veins. Here we describe a 73-year-old woman who was admitted to the hospital with clinical evidence of encephalopathy and was found to have hyperammonemia. Abdominal computed tomography angiography was performed and revealed a dilated portal vein measuring up to 1.

Magnetic Resonance Image findings of Spinal Tuberclosis at first presentation.

Background: Spinal tuberculosis presents in various pathological patterns. The clinical presentation and often the management depend on exact pathological findings. Objective of study was to evaluate the Pathology of spinal tuberculosis as depicted by MRI findings in 119 consecutive cases of spinal TB.

Lumbar disc degenerative disease: disc degeneration symptoms and magnetic resonance image findings.

Study Design: Cross sectional and observational.

Purpose: To evaluate the different aspects of lumbar disc degenerative disc disease and relate them with magnetic resonance image (MRI) findings and symptoms.

Overview Of Literature: Lumbar disc degenerative disease has now been proven as the most common cause of low back pain throughout the world.

Association of socioeconomic classes with diet, stress and hypertension.

Objective: To evaluate the relationship between diet and socioeconomic conditions and find out the prevalence of stress and Hypertension in different socioeconomic classes.

Methods: A cross-sectional study was conducted from May 2010 to October 2011, 176 people from four different socio economic Strata (low class, low middle class, upper middle class, and high class) were selected, which were defined on the basis of monthly income. Complete dietary intake was assessed with the last 3 days' dietary record, dietary patterns and restrictions.

Carcinogenesis of PIK3CA.

PIK3CA is the most frequently mutated oncogene in human cancers. PIK3CA is phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha. It controls cell growth, proliferation, motility, survival, differentiation and intracellular trafficking.

Hedgehog pathway inhibitors - current status and future prospects.

The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers. Hedgehog pathway inhibitors are a relatively new class of therapeutic agents that act by targeting the proteins involved in the regulation of Hh pathway (PTCH, SMO and Gli).