Publications by authors named "Arrigo Lessana"
Background: ST2 is a member of the interleukin-1 receptor family that is markedly upregulated in cultured cardiomyocytes subjected to mechanical strain. Serum soluble ST2 (sST2) levels can be detected in patients with acute myocardial infarction and severe chronic heart failure. This study sought to assess for the first time the activation of the ST2 pathway in patients with severe chronic degenerative mitral regurgitation.
View Article and Find Full Text PDFObjectives: To evaluate a new surgical technique for the correction of anterior mitral leaflet prolapse.
Methods: From October 2006 to November 2011, 44 consecutive patients (28 males, mean age 55 ± 13 years) underwent mitral valve repair because of anterior mitral leaflet prolapse. Echocardiography was performed to evaluate the distance from the tip of each papillary muscle to the annular plane.
Objective: Mechanisms of sepsis-induced myocardial and diaphragmatic alteration are multiple and remain largely unknown, particularly in humans. In the present study, we compared the inducible nitric oxide synthase (NOS-2) expression, the peroxynitrite production and the expression and activation of the ubiquitin proteolytic pathway in the wall of the 4 cardiac chambers, in the diaphragm, and in the rectus abdominis.
Patients: Seven patients who died from septic shock associated with a myocardial depression and 5 nonseptic (control) patients.
In order to analyze the quality of life (QoL) or frailty after AVR for octogenarians, we studied 84 patients older than 80 years who underwent aortic valve replacement alone or in combination with coronary artery bypass, between April 1998 and December 2001. Follow-up was performed in May 2002 with a telephonic interview to evaluate the self-rated QoL, health, and three frailty markers: falls, activity of daily living (ADL) and mood disorder. In-hospital mortality was 16.
View Article and Find Full Text PDFA novel technique of utilizing artificial chordae for repair of mitral valve prolapse.
J Thorac Cardiovasc Surg
October 2007
Background: Systolic anterior motion of the mitral valve causing left ventricular outflow tract obstruction is an uncommon complication of mitral valve repair that may necessitate immediate additional surgical action. We prospectively evaluated the technique of the edge-to-edge suture on post-mitral repair systolic anterior motion, which persisted despite conservative treatment.
Methods: From March 2002 to March 2004, 4 of 112 patients requiring mitral valve repair surgery for chronic degenerative mitral regurgitation had systolic anterior motion with severe left ventricular outflow tract obstruction and mitral regurgitation.
Objective: Esmolol, an ultra-short-acting beta-blocker, is known to attenuate myocardial ischemia-reperfusion injury. The aim of this study was to compare the effects of esmolol and potassium on myocardial metabolism during continuous normothermic retrograde blood cardioplegia.
Methods: Forty-one patients operated on for isolated aortic valve stenosis were randomly assigned to continuous coronary infusion with either potassium or esmolol during cardiopulmonary bypass.
Article Synopsis
- The study aimed to assess how often patients experience no hyperlactatemia (NHL), immediate hyperlactatemia (IHL), or late hyperlactatemia (LHL) after cardiac surgery, along with their associated risk factors and outcomes.
- Conducted in a cardiac surgery ICU, the research involved 325 patients undergoing cardiopulmonary bypass (CPB) and measured lactate levels at various times post-surgery.
- The findings revealed that IHL upon ICU admission was linked to higher mortality rates compared to NHL and LHL, with specific risk factors identified, indicating that elevated lactate levels can predict patient outcomes following cardiac surgery.
Total replacement of the ascending aorta without circulatory arrest.
J Thorac Cardiovasc Surg
January 2003
Objective: If the aortic arch is clamped between the brachiocephalic trunk and the left common carotid artery and the brachiocephalic trunk is also clamped, the total ascending aorta can be replaced without circulatory arrest. Candidates for this technique need to have the following characteristics: preoperative demonstration of Willis polygon patency by means of transcranial Doppler ultrasonography, preoperative computed tomographic scan that shows no calcification in the arch or in the brachiocephalic trunk, and preoperative or intraoperative evidence of separate origins of the brachiocephalic trunk and the left common carotid artery.
Methods: In three different institutions (with different time frames in each) from December 2000 to December 2001, the possibility of replacing the total ascending aorta without circulatory arrest was evaluated in 14 cases.