Preclinical evaluation of polymer encapsulated carbon-based nano and microparticles for sentinel lymph node tattooing.

Selective sentinel lymph node biopsy (SNLB) is the standard method for detecting regional metastases in breast cancer patients. Identifying affected axillary lymph nodes before neoadjuvant treatment is crucial, as such treatment may alter drainage pathways and lymph node morphology, hindering the identification of sentinel lymph nodes. The use of carbon-based tattooing on sentinel lymph nodes (SLN) has been employed as a permanent tattooing method in clinical studies of Targeted Axillary Dissection (TAD), aiding in the SLN identification during surgery.

Association between missense variants of uncertain significance in the gene and hereditary breast cancer: a cosegregation and bioinformatics analysis.

Inherited mutations in the gene have been associated with an increased lifetime risk of developing breast cancer (BC). We aim to identify in the study population the prevalence of mutations in the gene in diagnosed BC patients, evaluate the phenotypic characteristics of the tumor and family history, and predict the deleteriousness of the variants of uncertain significance (VUS). A genetic study was performed, from May 2016 to April 2020, in 396 patients diagnosed with BC at the University Hospital Lozano Blesa of Zaragoza, Spain.

Correction: observation of the on-surface thermal dehydrogenation of -octane on Pt(111).

Correction for ' observation of the on-surface thermal dehydrogenation of -octane on Pt(111)' by Daniel Arribas , , 2023, https://doi.org/10.1039/d3nr02564k.

Adult-born granule cells improve stimulus encoding and discrimination in the dentate gyrus.

Heterogeneity plays an important role in diversifying neural responses to support brain function. Adult neurogenesis provides the dentate gyrus with a heterogeneous population of granule cells (GCs) that were born and developed their properties at different times. Immature GCs have distinct intrinsic and synaptic properties than mature GCs and are needed for correct encoding and discrimination in spatial tasks.

observation of the on-surface thermal dehydrogenation of -octane on Pt(111).

The catalytic dehydrogenation of alkanes constitutes a key step for the industrial conversion of these inert sp-bonded carbon chains into other valuable unsaturated chemicals. To this end, platinum-based materials are among the most widely used catalysts. In this work, we characterize the thermal dehydrogenation of -octane (-CH) on Pt(111) under ultra-high vacuum using synchrotron-radiation X-ray photoelectron spectroscopy, temperature-programmed desorption and scanning tunneling microscopy, combined with calculations.

Liver tissue remodeling following ablation with irreversible electroporation in a porcine model.

Irreversible electroporation (IRE) is a method of non-thermal focal tissue ablation characterized by irreversibly permeabilizing the cell membranes while preserving the extracellular matrix. This study aimed to investigate tissue remodeling after IRE in a porcine model, especially focusing on the extracellular matrix and hepatic stellate cells. IRE ablation was performed on 11 female pigs at 2,000 V/cm electric field strength using a versatile high-voltage generator and 3 cm diameter parallel-plate electrodes.

Differences in temporal processing speeds between the right and left auditory cortex reflect the strength of recurrent synaptic connectivity.

Brain asymmetry in the sensitivity to spectrotemporal modulation is an established functional feature that underlies the perception of speech and music. The left auditory cortex (ACx) is believed to specialize in processing fast temporal components of speech sounds, and the right ACx slower components. However, the circuit features and neural computations behind these lateralized spectrotemporal processes are poorly understood.

Relevant SARS-CoV-2 viremia is associated with COVID-19 severity: Prospective cohort study and validation cohort.

Early kinetics of SARS-CoV-2 viral load (VL) in plasma determined by quantitative reverse-transcription polymerase chain reaction (RT-PCR) was evaluated as a predictor of poor clinical outcome in a prospective study and assessed in a retrospective validation cohort. Prospective observational single-center study including consecutive adult patients hospitalized with COVID-19 between November 2020 and January 2021. Serial plasma samples were obtained until discharge.

SARS-CoV-2 Viremia Precedes an IL6 Response in Severe COVID-19 Patients: Results of a Longitudinal Prospective Cohort.

Background: Interleukin 6 (IL6) levels and SARS-CoV-2 viremia have been correlated with COVID-19 severity. The association over time between them has not been assessed in a prospective cohort. Our aim was to evaluate the relationship between SARS-CoV-2 viremia and time evolution of IL6 levels in a COVID-19 prospective cohort.

[Knowledge of HIV and sexually-transmitted diseases in Latin American and Maghrebi immigrants in Catalonia (Spain)].

Objectives: To describe and compare levels of knowledge about HIV/AIDS and condom use in the immigrant population.

Method: We performed a cross-sectional study by means of a semi-structured questionnaire and face-to face interviews in 238 Latin American and Maghrebi users of medical centers in the Barcelona and North Barcelona-Maresme health areas. The questionnaire included sociodemographic variables and questions on sexual behavior and general knowledge about HIV/AIDS, transmission mechanisms, and means of prevention.

Obesity surgery results depending on technique performed: long-term outcome.

Background: Many techniques have excellent results at 2 years of follow-up but some matters regarding their long-term efficacy have arisen. This is why bariatric surgery results must be analyzed in long-term follow-up. The aim of this study was to extend the analysis over 5 years, evaluating weight loss, morbidity, and mortality of the surgical procedures performed.

Incidence of incisional hernia following vertical banded gastroplasty.

Background: Our aim was to determine which patient-related factors influence the incidence of incisional hernia after vertical banded gastroplasty for morbid obesity.

Methods: We reviewed the medical records of 80 morbidly obese patients operated on between 1986 and 1993. All the operations were performed by only one surgeon, and the midline laparotomy was closed by means of continuous polyglactin 910 suture.

Retroperitoneal mucinous cystadenoma.

Introduction: Retroperitoneal mucinous cystadenomas are rare tumors. Only 25 cases have been reported in the English literature until 2002. The histogenesis is unclear, diagnosis is never made preoperatively and surgery is the only treatment.

Transanal full-thickness excision of rectal tumours: should the defect be sutured? a randomized controlled trial.

PURPOSE: It is generally recommended that the defect, after full thickness total wall excision of a tumour located in the extraperitoneal part of the rectum, should be sutured. There is a lack of controlled studies however, supporting this approach. The aim of this study was to compare the results obtained in patients after peranal local excision of rectal tumours whose defect were sutured with those that were not.

Is endosonography useful to select patients for endoscopic treatment of rectal cancer?

Aim: in recent years there have been remarkable advances in the treatment of rectal cancer, stimulated by a general tendency towards conservative treatment, and aided by the development of diagnostic tools that allow the surgeon to select the most suitable tumors for treatment. In some cases, conservative local excision by transanal endoscopic microsurgery (TEM) may be appropriate. We analyzed the value of transrectal endosonography for the preoperative staging of rectal cancer previous to TEM.