Publications by authors named "Arquie C"
Objective: To determine the effects of fluorinated glucocorticoids on the occurrence and extent of ischaemic-like excitotoxic grey and white matter cerebral injuries in an animal model.
Design: A study of the influence of single or repeated doses of glucocorticoids when creating excitotoxic lesions in mice pups, mimicking some aspects of periventricular leucomalacia and cortical-subcortical stroke as observed in human neonates.
Sample: Four hundred and sixty-seven mouse pups out of more than 30 litters.
VIP and PACAP 38 modulate ibotenate-induced neuronal heterotopias in the newborn hamster neocortex.
J Neuropathol Exp Neurol
December 2000
Article Synopsis
- Ibotenate, when administered to newborn hamsters, causes neuronal heterotopias in the brain, with different doses leading to distinct patterns of abnormalities.
- Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) can influence these formations by interacting with specific receptors (VPAC1 and VPAC2) and signaling pathways.
- Co-treatment with VIP alters the effects of ibotenate, suggesting that these neurotrophic peptides play a role in managing excitotoxicity and neuronal migration through the cAMP-PKA pathway.